CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022890
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coiled-coil domain-containing protein 39 
Protein Synonyms/Alias
  
Gene Name
 CCDC39 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
743VDEKYRYKQRQIRELmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. 
Sequence Annotation
  
Keyword
 Alternative splicing; Cell projection; Ciliopathy; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Primary ciliary dyskinesia; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 941 AA 
Protein Sequence
MSSEFLAELH WEDGFAIPVA NEENKLLEDQ LSKLKDERAS LQDELREYEE RINSMTSHFK 60
NVKQELSITQ SLCKARERET ESEEHFKAIA QRELGRVKDE IQRLENEMAS ILEKKSDKEN 120
GIFKATQKLD GLKCQMNWDQ QALEAWLEES AHKDSDALTL QKYAQQDDNK IRALTLQLER 180
LTLECNQKRK ILDNELTETI SAQLELDKAA QDFRKIHNER QELIKQWENT IEQMQKRDGD 240
IDNCALELAR IKQETREKEN LVKEKIKFLE SEIGNNTEFE KRISVADRKL LKCRTAYQDH 300
ETSRIQLKGE LDSLKATVNR TSSDLEALRK NISKIKKDIH EETARLQKTK NHNEIIQTKL 360
KEITEKTMSV EEKATNLEDM LKEEEKDVKE VDVQLNLIKG VLFKKAQELQ TETMKEKAVL 420
SEIEGTRSSL KHLNHQLQKL DFETLKQQEI MYSQDFHIQQ VERRMSRLKG EINSEEKQAL 480
EAKIVELRKS LEEKKSTCGL LETQIKKLHN DLYFIKKAHS KNSDEKQSLM TKINELNLFI 540
DRSEKELDKA KGFKQDLMIE DNLLKLEVKR TREMLHSKAE EVLSLEKRKQ QLYTAMEERT 600
EEIKVHKTML ASQIRYVDQE RENISTEFRE RLSKIEKLKN RYEILTVVML PPEGEEEKTQ 660
AYYVIKAAQE KEELQREGDC LDAKINKAEK EIYALENTLQ VLNSCNNNYK QSFKKVTPSS 720
DEYELKIQLE EQKRAVDEKY RYKQRQIREL QEDIQSMENT LDVIEHLANN VKEKLSEKQA 780
YSFQLSKETE EQKPKLERVT KQCAKLTKEI RLLKDTKDET MEEQDIKLRE MKQFHKVIDE 840
MLVDIIEENT EIRIILQTYF QQSGLELPTA STKGSRQSSR SPSHTSLSAR SSRSTSTSTS 900
QSSIKVLELK FPASSSLVGS PSRPSSASSS SSNVKSKKSS K 941 
Gene Ontology
 GO:0035085; C:cilium axoneme; IDA:UniProtKB.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
 GO:0070286; P:axonemal dynein complex assembly; IMP:UniProtKB.
 GO:0060285; P:ciliary cell motility; IMP:UniProtKB.
 GO:0071907; P:determination of digestive tract left/right asymmetry; IMP:BHF-UCL.
 GO:0071910; P:determination of liver left/right asymmetry; IMP:BHF-UCL.
 GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:BHF-UCL.
 GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IMP:UniProtKB.
 GO:0060286; P:flagellar cell motility; IMP:UniProtKB.
 GO:0001947; P:heart looping; IMP:BHF-UCL.
 GO:0030324; P:lung development; IMP:BHF-UCL. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS