UniProt Accession

 G3V4Z4_HUMAN; G3V4Z4 

Genbank Protein ID

 AC005484 

Genbank Nucleotide ID

  

Protein Name

 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 ALDH6A1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	PLITPQAKERVCNLI	acetylation	[1]
81	PLITPQAKERVCNLI	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; IEA:InterPro.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS 

PRINTS