Tag | Content |
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CPLM ID | CPLM-005714 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Retinoic acid receptor RXR-gamma |
Protein Synonyms/Alias | Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma |
Gene Name | Rxrg |
Gene Synonyms/Alias | Nr2b3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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382 | VLFNPDAKGLSNPSE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). |
Sequence Annotation | DNA_BIND 139 204 Nuclear receptor. ZN_FING 139 159 NR C4-type. ZN_FING 175 199 NR C4-type. REGION 1 138 Modulating (By similarity). REGION 205 260 Hinge. REGION 261 463 Ligand-binding (By similarity). |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 463 AA |
Protein Sequence | MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV SAPRTLSAVG 60 TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG 120 IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD 180 CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECASSS HEDMPVERIL 240 EAELAVEPKT ESYGDMNVEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI 300 LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD 360 MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL 420 LRLPALRSIG LKCLEHLFFF KLIGDTPIDS FLMEMLETPL QIT 463 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004886; F:9-cis retinoic acid receptor activity; IDA:MGI. GO:0043565; F:sequence-specific DNA binding; IGI:MGI. GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007507; P:heart development; IEA:Compara. GO:0030182; P:neuron differentiation; IEA:Compara. GO:0007422; P:peripheral nervous system development; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. GO:0031641; P:regulation of myelination; IEA:Compara. GO:0032526; P:response to retinoic acid; IEA:Compara. GO:0007519; P:skeletal muscle tissue development; IEA:Compara. |
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