| Tag | Content |
|---|
| CPLM ID | CPLM-023567 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anaphase-promoting complex subunit 7 |
Protein Synonyms/Alias | APC7; Cyclosome subunit 7; Prediabetic NOD sera-reactive autoantigen |
Gene Name | Anapc7 |
Gene Synonyms/Alias | Apc7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 146 | MMLANLYKKAGQERP | ubiquitination | [1] | | 259 | DSKNSVLKFEQAQML | ubiquitination | [1] | | 433 | KAKTLLDKALAQRPD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
Sequence Annotation | REPEAT 43 76 TPR 1.
REPEAT 135 168 TPR 2.
REPEAT 237 270 TPR 3.
REPEAT 339 372 TPR 4.
REPEAT 407 441 TPR 5.
REPEAT 442 474 TPR 6.
REPEAT 475 508 TPR 7. |
Keyword | Cell cycle; Cell division; Complete proteome; Mitosis; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 565 AA |
Protein Sequence | MSVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPS QKYQLLVYHA DSLFHDKEYR 60
NAVSKYAMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS EIEVKYKMAE CYTMLKLDKD 120
AIAVLDGIPS RQRTPKINMM LANLYKKAGQ ERPSVTSYKE VLRQCPLALD AILGLLSLSV 180
KGAEVASMTM NVIQTVPNLD WLSVWIKAYA FVHTGDNSRA INTICSLEKK SLLRDNVDLL 240
GSLADLYFRA GDSKNSVLKF EQAQMLDPYL IRGMDVYGYL LAREGRLEDV ENLGCRLFNI 300
SDQHAEPWVV SGCHSFYSKR YSRALYLGAK AIQLNSNSVQ ALLLKGAALR NMGRVQEAII 360
HFREAIRLAP CRLDCYEGLI ECYLASNSIR EAMVMANNVY KTLGANAQTL TLLATVCLED 420
PVTQEKAKTL LDKALAQRPD YVKAVVKKAE LLSREQKYED GIALLRNALA NQSDCVLHRI 480
LGDFLVAVNE YQEAMDQYSI ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG 540
EEGDLEGSDS EAAQWADQEQ WFGMQ 565 |
Gene Ontology | GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB. |
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Pfam | |
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PROSITE | |
PRINTS | |