CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004642
UniProt Accession
Genbank Protein ID
 M35520 
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-5A 
Protein Synonyms/Alias
  
Gene Name
 RAB5A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Canis familiaris (Dog) (Canis lupus familiaris) 
NCBI Taxa ID
 9615 
Lysine Modification
Position
Peptide
Type
References
134VIALSGNKADLANKRubiquitination[1]
140NKADLANKRAVDFQEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension (By similarity). 
Sequence Annotation
 NP_BIND 27 35 GTP (By similarity).
 NP_BIND 75 79 GTP (By similarity).
 NP_BIND 133 136 GTP (By similarity).
 NP_BIND 163 165 GTP (By similarity).
 MOTIF 49 57 Effector region (Potential).
 LIPID 212 212 S-geranylgeranyl cysteine (By
 LIPID 213 213 S-geranylgeranyl cysteine (By  
Keyword
 Cell membrane; Cell projection; Complete proteome; Cytoplasmic vesicle; Differentiation; Endosome; GTP-binding; Lipoprotein; Membrane; Neurogenesis; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 215 AA 
Protein Sequence
MANRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ 60
TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR 120
QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK 180
LPKNEPQNPG ANSARGRGVD LTEPTQPTRS QCCSN 215 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; ISS:UniProtKB.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0045921; P:positive regulation of exocytosis; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:2000286; P:receptor internalization involved in canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0051489; P:regulation of filopodium assembly; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.