UniProt Accession

 CRIP2_MOUSE; Q9DCT8 

Genbank Protein ID

 AF469648; AF470625; AF450245; AK002484; BC002093; BC002096 

Genbank Nucleotide ID

 AAM89218.1; AAM89219.1; AAM97586.1; BAB22136.1; AAH02093.1; AAH02096.1 

Protein Name

 Cysteine-rich protein 2 

Protein Synonyms/Alias

 CRP-2; Heart LIM protein 

Gene Name

 Crip2 

Gene Synonyms/Alias

 Crp2; Hlp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	KTVYFAEKVSSLGKD	acetylation	[1]
17	KTVYFAEKVSSLGKD	ubiquitination	[2]
23	EKVSSLGKDWHKFCL	acetylation	[1]
112	GPPKGPSKASSVTTF	ubiquitination	[2]
138	KRVYFAEKVTSLGKD	acetylation	[1, 3]
138	KRVYFAEKVTSLGKD	ubiquitination	[2]
144	EKVTSLGKDWHRPCL	acetylation	[1]
200	VGSYIYDKDPEGTVQ	acetylation	[4]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

  

Sequence Annotation

 DOMAIN 5 57 LIM zinc-binding 1.
 DOMAIN 126 178 LIM zinc-binding 2.
 MOD_RES 138 138 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030097; P:hemopoiesis; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS