CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014411
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myomesin-1 
Protein Synonyms/Alias
 Myomesin family member 1; Skelemin 
Gene Name
 Myom1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96QGSEVSRKTASAYDYubiquitination[1]
122LLEDYSSKLSPQTKRubiquitination[1]
171DSEEERIKEAAAYIAubiquitination[1]
180AAAYIAQKTLLASEEubiquitination[1]
193EEAIAASKQSTASKQubiquitination[1]
219QREETFEKKSRNIAIubiquitination[1]
229RNIAIREKAEELSLKubiquitination[1]
237AEELSLKKTLEETQTubiquitination[1]
263HAPEFIIKPRSHTVWubiquitination[1]
272RSHTVWEKENVKLHCubiquitination[1]
354SVVVKRYKGELDESLubiquitination[1]
415VVITPEIKHFQPEVQacetylation[2]
415VVITPEIKHFQPEVQubiquitination[1]
569FRVRAVNKTGIGLPSubiquitination[1]
590AALDPAEKARLKSHPubiquitination[1]
655GIMYFVEKCDVGAENubiquitination[1]
673VNTELPVKSPRFALFubiquitination[1]
686LFDLVEGKSYRFRVRubiquitination[1]
715EVTVVGDKLDIPKAPubiquitination[1]
964VVGEVPGKWREANIKubiquitination[1]
979AVSDAAYKISNLKENubiquitination[1]
1060TGYFVDLKEASAKDDubiquitination[1]
1080NEAAIVNKYLRVQGLubiquitination[1]
1088YLRVQGLKEGTSYVFubiquitination[1]
1155KSEFVWSKDYVPTEDubiquitination[1]
1171PRLEVENKGDKTKMTubiquitination[1]
1250RFWMQAEKLSSNAKVubiquitination[1]
1256EKLSSNAKVSYIFNEubiquitination[1]
1264VSYIFNEKEIFEGPKubiquitination[1]
1325DVYKKLQKEAEFQRQubiquitination[1]
1482SHNGTGIKYTDRVKSubiquitination[1]
1510PTPNDKGKYVMELFDubiquitination[1]
1519VMELFDGKTGHQKTVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins. 
Sequence Annotation
 DOMAIN 258 349 Ig-like C2-type 1.
 DOMAIN 376 478 Ig-like C2-type 2.
 DOMAIN 490 582 Fibronectin type-III 1.
 DOMAIN 618 710 Fibronectin type-III 2.
 DOMAIN 719 809 Fibronectin type-III 3.
 DOMAIN 916 1011 Fibronectin type-III 4.
 DOMAIN 1021 1115 Fibronectin type-III 5.
 DOMAIN 1114 1212 Ig-like C2-type 3.
 DOMAIN 1340 1426 Ig-like C2-type 4.
 DOMAIN 1555 1644 Ig-like C2-type 5.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Immunoglobulin domain; Muscle protein; Reference proteome; Repeat; Thick filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1667 AA 
Protein Sequence
MSLPFYQRSH QHYDLSYRNK DLRTTMSHYQ QEKKRSAVYT HGSTAYSSRS LAARRQESEA 60
FSQASATSYQ QQASQTYSLG ASSSSRHSQG SEVSRKTASA YDYGYSHGLT DSSLLLEDYS 120
SKLSPQTKRA KRSLLSGEET GSLPGNYLVP IYSGRQVHIS GIRDSEEERI KEAAAYIAQK 180
TLLASEEAIA ASKQSTASKQ SATSKRTTST LQREETFEKK SRNIAIREKA EELSLKKTLE 240
ETQTYHGKLN EDHLLHAPEF IIKPRSHTVW EKENVKLHCS VAGWPEPRLT WYKNQVPINV 300
HANPGKYIIE SRYGMHTLEI SKCDFEDTAQ YRASAMNVQG ELSAYASVVV KRYKGELDES 360
LLRGGVSMPL SFAVTPYGYA SKFEIHFDDK FDVSFGREGE TMSLGCRVVI TPEIKHFQPE 420
VQWYRNGAPV SPSKWVQPHW SGDRATLTFS HLNKEDEGLY TIRVRMGEYY EQYSAYVFVR 480
DADAEIEGAP AAPLDVVSLD ANKDYIIISW KQPAVDGGSP ILGYFIDKCE VGTDTWSQCN 540
DTPVKFARFP VTGLIEGRSY IFRVRAVNKT GIGLPSRVSE PVAALDPAEK ARLKSHPSAP 600
WTGQIIVTEE EPTEGVIPGP PTDLSVTEAT RSYVVLSWKP PGQRGHEGIM YFVEKCDVGA 660
ENWQRVNTEL PVKSPRFALF DLVEGKSYRF RVRCSNSAGV GEPSETTEVT VVGDKLDIPK 720
APGKIIPSRN TDTSVVVSWE ESRDAKELVG YYIEASVVGS GKWEPCNNNP VKGSRFTCHG 780
LTTAQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIGGGVS PDVWPQLSDT PGGLTDSRGG 840
MNGASPPTSQ KDALLGSNPN KPSPPSSPSS RGQKEVSTVS ESVQEPLSSP PQEAAPEEEQ 900
SQSEPPKKKK DPVAVPSAPY DITCLESFRD SMVLGWKQPD TTGGAEITGY YVNYREVVGE 960
VPGKWREANI KAVSDAAYKI SNLKENTLYQ FQVSAMNIAG LGAPSTVSEC FKCEEWTIAV 1020
PGPPHSVKLS EVRKNSLVLQ WKPPVYSGRT PVTGYFVDLK EASAKDDQWR GLNEAAIVNK 1080
YLRVQGLKEG TSYVFRVRAV NQAGVGKPSD LAGPVVAETR PGTKEVVVSV DDDGVISLNF 1140
ECDQMTPKSE FVWSKDYVPT EDSPRLEVEN KGDKTKMTFK DLGTDDLGTY SCDVTDTDGI 1200
ASSYLIDEEE MKRLLALSQE HKFPTVPTKS ELAVEILEKG QVRFWMQAEK LSSNAKVSYI 1260
FNEKEIFEGP KYKMHIDRNT GIIEMFMEKL QDEDEGTYTF QIQDGKATGH STLVLIGDVY 1320
KKLQKEAEFQ RQEWIRKQGP HFAEYLSWEV TGECNVLLKC KVANIKKETH IVWYKDEREI 1380
SVDEKHDFKD GICTLLITEF SKKDAGFYEV ILKDDRGKDK SRLKLVDEAF QDLMTEVCKK 1440
IALSATDLKI QSTAEGIRLY SFVCYYLDDL KVNWSHNGTG IKYTDRVKSG VTGEQIWLQI 1500
NEPTPNDKGK YVMELFDGKT GHQKTVDLSG QAFDEAFAEF QRLKQAAIAE KNRARVLGGL 1560
PDVVTIQEGK ALNLTCNVWG DPPPEVSWLK NEKPLTSDDH CSLKFEAGKT AFFTISGVST 1620
ADSGKYGLVV KNKYGSETSD FTVSVFIPEE ELRKGAMEPP KGNQKSK 1667 
Gene Ontology
 GO:0005856; C:cytoskeleton; TAS:MGI.
 GO:0031430; C:M band; IDA:UniProtKB.
 GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0006936; P:muscle contraction; IDA:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS