| Tag | Content |
|---|
| CPLM ID | CPLM-010792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Resistance to glucose repression protein 1 |
Protein Synonyms/Alias | Protein HEX2; Second-site suppressor of the rna1-1 mutation 1 |
Gene Name | REG1 |
Gene Synonyms/Alias | HEX2; PZF240; SPP43; SRN1; YDR028C; YD9813.06C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 166 | DYLSHEWKESEISNS | ubiquitination | [1] | | 260 | GSDDENSKRISMPTK | ubiquitination | [1] | | 277 | KSIAAAPKPILKKRT | ubiquitination | [1] | | 700 | KHVPQLHKASANNTT | ubiquitination | [1] | | 882 | KALPKQPKASDSSQS | ubiquitination | [1] | | 960 | ASKLKDKKVDSVQTT | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Involved in RNA processing and negative regulation of glucose repression. Regulates the level of two antigens, P43 and P70. Binds to protein phosphatase type 1. Functions with REG2 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly. |
Sequence Annotation | MOTIF 277 283 Nuclear localization signal (Potential).
MOTIF 595 599 Nuclear localization signal (Potential).
MOTIF 873 879 Nuclear localization signal (Potential).
MOD_RES 2 2 N-acetylserine.
MOD_RES 75 75 Phosphoserine.
MOD_RES 242 242 Phosphoserine.
MOD_RES 254 254 Phosphoserine.
MOD_RES 311 311 Phosphoserine.
MOD_RES 421 421 Phosphoserine.
MOD_RES 480 480 Phosphotyrosine.
MOD_RES 490 490 Phosphoserine.
MOD_RES 570 570 Phosphoserine.
MOD_RES 572 572 Phosphoserine.
MOD_RES 576 576 Phosphoserine.
MOD_RES 610 610 Phosphoserine.
MOD_RES 614 614 Phosphoserine.
MOD_RES 680 680 Phosphoserine.
MOD_RES 896 896 Phosphothreonine.
MOD_RES 898 898 Phosphoserine.
MOD_RES 980 980 Phosphoserine. |
Keyword | Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1014 AA |
Protein Sequence | MSTNLANYFA GKKDIENEHV NRNASHESNS KSDVKISGND NDNDEDMGPS VSMAVQAKND 60
DDFHKSTFNL KRTRSMGLLD EYIDPTKKLL GRSDDLYDND NEYYDNSSNN SSSNSSDDDY 120
DDGYQEHSTS VSPPPADNDS YLIPQDDNDV VVEPERHVDY LSHEWKESEI SNSWKYIILK 180
KKKRDVDLVN AARLENASWR TWAKARNNLK TVSPEVVNWS KDSDVTWLYG PIVRDSEGNA 240
QSEEEHDLER GYGSDDENSK RISMPTKNSK SIAAAPKPIL KKRTVTEIIE DNALWKLNEA 300
RKHMTEMKHA SVIMDPNGNK NVHDDFDALA AQVNAQYYHY PKESNSSVSL KSQHSDKKDN 360
STIPNPVGEN SNGGGDKGEE DLHLKSALHV QNNRSTAQSN KSILENSTND RKANLDQNLN 420
SPDNNRFPSS TSSSNRDNEN NSMGLSSILT SNPSEKSNKP TKNRHIHFND RVEQCMALRY 480
PASQSEDDES DDENKQYVDV NNNANVTTIN NNRTPLLAIQ HKSIPINSAT EHLNKNTSDD 540
DTSSQSSSSS HSDDEEHGGL YINARFSRRS DSGVHSPITD NSSVASSTTS RAHVRPIIKL 600
LPDTTLNYGS DEESDNGEFN GYGNAVSHNV NTSRGYDYIY DYNSVYTGDT SSFLPVDSCD 660
IVDVPEGMDL QTAIADDNAS NYEFNNAVES KEKHVPQLHK ASANNTTRQH GSHMLLYDDD 720
NYSSSSDSEQ QFIEDSQYNS SDDEEEEDDD DQEVDDNHDE GLSLRRTLSL GKSGSTNSLY 780
DLAQPSLSSA TPQQKNPTNF TGGKTDVDKD AQLAVRPYPL KRNSSSGNFI FNSDSEEESS 840
SEEEQRPLPA NSQLVNRSVL KGSVTPANIS SQKKKALPKQ PKASDSSQSF RIVNNTPSPA 900
EVGASDVAIE GYFSPRNESI KSVVSGGNMM DHQDHSEMDT LAKGFENCHI NNASKLKDKK 960
VDSVQTTRKE ASLTDSSNES LHKVVQNARG MASKYLHSWK KSDVKPQENG NDSS 1014 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0000164; C:protein phosphatase type 1 complex; TAS:SGD. GO:0008599; F:protein phosphatase type 1 regulator activity; TAS:SGD. GO:0042149; P:cellular response to glucose starvation; IMP:SGD. GO:0005977; P:glycogen metabolic process; TAS:SGD. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:SGD. GO:0006109; P:regulation of carbohydrate metabolic process; TAS:SGD. GO:0007039; P:vacuolar protein catabolic process; IDA:SGD. |
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PROSITE | |
PRINTS | |