CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycine N-acyltransferase-like protein 
Protein Synonyms/Alias
 Acyl-CoA:glycine N-acyltransferase-like; AAc-like 
Gene Name
 Gm4952 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19MLESSLRKYLPESLKacetylation[1]
19MLESSLRKYLPESLKubiquitination[2]
41MNQGNPFKLKALVDKacetylation[3]
43QGNPFKLKALVDKWPacetylation[3]
48KLKALVDKWPDFNTVacetylation[3]
80NTYQIYSKDPKHCLEacetylation[3]
83QIYSKDPKHCLEFLGacetylation[1, 3]
140YMMPETAKKLVPSLLacetylation[3]
150VPSLLEDKEYLDHQSacetylation[3]
169AIDQEMFKLSTLDVTacetylation[3]
183THAPLVDKFWQFGGNacetylation[3]
256AQTLAMDKRGYPVYNacetylation[3, 4, 5, 6]
256AQTLAMDKRGYPVYNsuccinylation[5]
270NHTEQTNKVIQKMSHacetylation[3, 4, 5]
270NHTEQTNKVIQKMSHsuccinylation[5]
Reference
 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
 Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity). 
Sequence Annotation
 MOD_RES 83 83 N6-acetyllysine.  
Keyword
 Acetylation; Acyltransferase; Complete proteome; Mitochondrion; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 296 AA 
Protein Sequence
MLHLRSSQML QMLESSLRKY LPESLKVYGT VFHMNQGNPF KLKALVDKWP DFNTVVVRPR 60
EQEMGDDLDQ HTNTYQIYSK DPKHCLEFLG TPDVINWKQH LQIQSSQSNL NEAIMDLAAG 120
KMVKVKRTQC ILYMMPETAK KLVPSLLEDK EYLDHQSGRP RAIDQEMFKL STLDVTHAPL 180
VDKFWQFGGN ERSQRFIGRC IQIFPSSCLL GPEGTPVSWA LMDQTGEIRM AGTVPDYRAQ 240
GLISHIIYAQ TLAMDKRGYP VYNHTEQTNK VIQKMSHTLH HVPMPCDWNQ WYCAPL 296 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0047961; F:glycine N-acyltransferase activity; IEA:EC. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR010313; Glycine_N-acyltransferase.
 IPR013652; Glycine_N-acyltransferase_C.
 IPR015938; Glycine_N-acyltransferase_N. 
Pfam
 PF08444; Gly_acyl_tr_C
 PF06021; Gly_acyl_tr_N 
SMART
  
PROSITE
  
PRINTS