CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017519
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 G patch domain-containing protein 11 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 75 
Gene Name
 GPATCH11 
Gene Synonyms/Alias
 CCDC75 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
72NALGCENKGFALLQKubiquitination[1, 2]
119HEASLKRKAEEKLESacetylation[3]
123LKRKAEEKLESYRKKacetylation[3, 4, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 DOMAIN 69 115 G-patch.
 MOD_RES 123 123 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MAEEEDYMSD SFINVQEDIR PGLPMLRQIR EARRKEEKQQ EANLKNRQKS LKEEEQERRD 60
IGLKNALGCE NKGFALLQKM GYKSGQALGK SGGGIVEPIP LNIKTGKSGI GHEASLKRKA 120
EEKLESYRKK IHMKNQAEEK AAEQFRMRLK NKQDEMKLEG DLRRSQRACQ QLDVQKNIQV 180
PREAWYWLRL EEETEEDEEE KEQDEDEYKS EDLSVLEKLQ ILTSYLREEH LYCIWCGTAY 240
EDKEDLSSNC PGPTSADHD 259 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR025239; DUF4187.
 IPR000467; G_patch_dom. 
Pfam
 PF13821; DUF4187
 PF01585; G-patch 
SMART
 SM00443; G_patch 
PROSITE
 PS50174; G_PATCH 
PRINTS