CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006677
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone morphogenetic protein receptor type-1A 
Protein Synonyms/Alias
 BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD292 
Gene Name
 BMPR1A 
Gene Synonyms/Alias
 ACVRLK3; ALK3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
207IPVGESLKDLIDQSQubiquitination[1]
232LVQRTIAKQIQMVRQubiquitination[2]
523RIKKTLAKMVESQDVubiquitination[1]
531MVESQDVKI******ubiquitination[1, 3, 4, 5]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. 
Sequence Annotation
 DOMAIN 204 233 GS.
 DOMAIN 234 525 Protein kinase.
 NP_BIND 240 248 ATP (By similarity).
 REGION 107 109 Mediates specificity for BMP ligand.
 ACT_SITE 362 362 Proton acceptor (By similarity).
 BINDING 261 261 ATP (By similarity).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 DISULFID 61 82
 DISULFID 63 67
 DISULFID 76 100
 DISULFID 110 124
 DISULFID 125 130  
Keyword
 3D-structure; ATP-binding; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK 60
CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120
TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC 180
KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240
GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360
RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420
HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480
PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532 
Gene Ontology
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IDA:HGNC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
 GO:0046332; F:SMAD binding; IDA:HGNC.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
 GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; TAS:Reactome.
 GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
 GO:0051216; P:cartilage development; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0009950; P:dorsal/ventral axis specification; IEA:Compara.
 GO:0007398; P:ectoderm development; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0003272; P:endocardial cushion formation; ISS:BHF-UCL.
 GO:0060914; P:heart formation; IEA:Compara.
 GO:0035137; P:hindlimb morphogenesis; IEA:Compara.
 GO:0006955; P:immune response; IMP:BHF-UCL.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0048368; P:lateral mesoderm development; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0048382; P:mesendoderm development; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0001880; P:Mullerian duct regression; IEA:Compara.
 GO:0050768; P:negative regulation of neurogenesis; IEA:Compara.
 GO:0014032; P:neural crest cell development; IEA:Compara.
 GO:0021998; P:neural plate mediolateral regionalization; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0048352; P:paraxial mesoderm structural organization; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0030501; P:positive regulation of bone mineralization; IMP:BHF-UCL.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
 GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0048378; P:regulation of lateral mesodermal cell fate specification; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc. 
Interpro
 IPR000472; Activin_rcpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR003605; TGF_beta_rcpt_GS. 
Pfam
 PF01064; Activin_recp
 PF00069; Pkinase
 PF08515; TGF_beta_GS 
SMART
 SM00467; GS 
PROSITE
 PS51256; GS
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS