UniProt Accession

 TOIP2_HUMAN; Q8NFQ8 

Genbank Protein ID

 AF464140; AL359853; BC101532; BC112225 

Genbank Nucleotide ID

 AAM50514.1; CAH70382.1; AAI01533.1; AAI12226.1 

Protein Name

 Torsin-1A-interacting protein 2 

Protein Synonyms/Alias

 Lumenal domain-like LAP1 

Gene Name

 TOR1AIP2 

Gene Synonyms/Alias

 LULL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
195	SHPQQTQKLEEIKEN	ubiquitination	[1, 2, 3]
200	TQKLEEIKENAQDTM	ubiquitination	[2, 4]
425	VRDLLWAKFTNSDTP	ubiquitination	[2]
442	FNHMDSDKLSGLWSR	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 163 163 Phosphoserine.
 CARBOHYD 289 289 N-linked (GlcNAc...) (Potential).  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 470 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. 

Interpro

 IPR008662; Lamina-ass_polypeptide_CLAP1C. 

Pfam

 PF05609; LAP1C 

SMART

  

PROSITE

  

PRINTS