CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 6 
Protein Synonyms/Alias
  
Gene Name
 Arhgef6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
628KSPKTMKKFLHKRKTacetylation[1]
718VDTVYALKDEVKELKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 772 AA 
Protein Sequence
MNPEERVVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLISRLLP GSVEKYCQEP 60
QTEADCIDNI NDFLKGCATL QVEVFEPDDL YSGANFSKVL NTLLAVNKAT EDQLSERPCG 120
RSSSLSATTS SQTNPQAAVP STTPEQQSEE KAAEMTENGS HQLIVKARFN FKQTNEDELS 180
VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKPS ERPLSPKAVK GFDTAPLTKN 240
YYTVVLQNIL DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EFTCLLGNFE EVCTFQQTLC 300
QALEECSKSP ENQHKVGGCL LNLMPHFKSM YLAYCANHPS AVNVLTQHSD DLERFMENQG 360
ASSPGILILT TSLSKPFMRL EKYVTLLQEL ERHMEDTHPD HQDILKAIIA FKSLMGQCQD 420
LRKRKQLELQ ILSEPIQAWE GDDIKTLGNV IFMSQVVMQH GACEEKEERY FLLFSSVLIM 480
LSASPRMSGF MYQGKVPIAG MVVTRLDEIE GNDCTFEITG STVERIVVHC NNNQDFQEWM 540
EQLNRLTKGP ASCSSLSKTS SSSCSTHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL 600
RPSAALGYKE VILLPLQESS KSPKTMKKFL HKRKTERKTS EEEYVIRKST AALEEDAQIL 660
KVIEAYCTSA SFQQGTRKDS VPQVLLPEEE KLIIEETRSN GQTIIEEKSL VDTVYALKDE 720
VKELKQQQAQ VWQCLSTILA TRKGRGRTVR ELLKQTDECI RAESSSKTSI LQ 772 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR001715; CH-domain.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00307; CH
 PF00169; PH
 PF00621; RhoGEF
 PF07653; SH3_2 
SMART
 SM00033; CH
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS50021; CH
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.