CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase Haspin homolog ALK1 
Protein Synonyms/Alias
 DNA damage-responsive protein ALK1 
Gene Name
 ALK1 
Gene Synonyms/Alias
 YGL021W; G3686 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
209NLPPTMGKKNSSIASubiquitination[1, 2]
210LPPTMGKKNSSIASTubiquitination[1, 2]
541KLKIMQQKFDGIPQLubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Serine/threonine haspin-like protein kinase involved in cell cycle regulation. 
Sequence Annotation
 DOMAIN 468 760 Protein kinase.
 NP_BIND 474 482 ATP (By similarity).
 MOTIF 200 202 KEN box.
 MOTIF 224 232 D box.
 BINDING 510 510 ATP (By similarity).
 MOD_RES 76 76 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.  
Keyword
 ATP-binding; Cell cycle; Complete proteome; DNA damage; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 760 AA 
Protein Sequence
MLLHFDIVIQ LLSSHTLKSH QVEPPMDFET SFEEFVEDKR FIALEVSDND DDCDTDLTAD 60
TADELESSAI LKMRESDASL NVTTGNNTSR KTTSNSKKRW SLLSNHSAVS SSKSKKRWSV 120
LSSSFTSESH KDRESRNVLQ QKRKSLQSYS SLDTVASNSS ISASSSLKRS STGLSLRQLF 180
TKIGINDDIS QPGIGIPQGK ENLPPTMGKK NSSIASTSSE NRLRTPLKPL VNHSKRPTSQ 240
PQQQQPLYNA SLSSRRSSIS STVSSSSSSK WRFWKRNKNQ TPALLQPDHH SLKTFPAVNR 300
RDSMTPVEPR NMVKHKTSFS DFHKTIFSSN TYSESSDTIS SMEITLKNKA SSSSLSLNVL 360
KKRNSQSSLK HKSSHASLQK FKRNKGKSSM IAPSTATNSS NDDSCSYSSK NSTLSHRISL 420
PVPDQVSRDK IQNKLRYSTS LLSLNSKSSL PMNKNDHDET LLRQILLNCD IKRILNPAKG 480
DVLPLINDVN HLSSIQLTSN VWQIGEVICK KVSLGTIDDI TWDRKFLSLQ ELEKLKIMQQ 540
KFDGIPQLLK SFVVKEANGG LYLYLLFKDH GTPISLISLK NWKQILKIFW SCAGIIHGLE 600
KNLKFEHRNL TLDNILIDGN GNITIIDFKC SRLQTPQDDV LYLRLDHPLF FLNGKDKSKI 660
NEYQYQFEFE IYQSMRILLN MDASAFEPMT NLYWLYYLSR VLLKFGDRKL GKNDANRDKM 720
ARVINHLEMN LAVHKRGGQL FKRLETEDIK NTGDLLKLYK 760 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:SGD.
 GO:0007067; P:mitosis; IEP:SGD.
 GO:0006974; P:response to DNA damage stimulus; IEA:UniProtKB-KW. 
Interpro
 IPR024604; DUF3635.
 IPR011009; Kinase-like_dom. 
Pfam
 PF12330; DUF3635 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM 
PRINTS