UniProt Accession

 IF2A_RAT; P68101; P05199 

Genbank Protein ID

 J02646; BC087019 

Genbank Nucleotide ID

 AAA41110.1; AAH87019.1 

Protein Name

 Eukaryotic translation initiation factor 2 subunit 1 

Protein Synonyms/Alias

 Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha 

Gene Name

 Eif2s1 

Gene Synonyms/Alias

 Eif2a 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
141	TAWVFDDKYKRPGYG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. 

Sequence Annotation

 DOMAIN 17 88 S1 motif.
 MOD_RES 49 49 Phosphoserine; by HRI (By similarity).
 MOD_RES 52 52 Phosphoserine; by EIF2AK3, GCN2, HRI and
 MOD_RES 141 141 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
 GO:0005850; C:eukaryotic translation initiation factor 2 complex; IEA:InterPro.
 GO:0005851; C:eukaryotic translation initiation factor 2B complex; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043022; F:ribosome binding; IEA:Compara.
 GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0043558; P:regulation of translational initiation in response to stress; IEA:Compara. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR024055; TIF2_asu_C.
 IPR024054; TIF2_asu_middle.
 IPR011488; TIF_2_asu. 

Pfam

 PF07541; EIF_2_alpha
 PF00575; S1 

SMART

 SM00316; S1 

PROSITE

 PS50126; S1 

PRINTS