UniProt Accession

 RM41_RAT; Q5BJX1 

Genbank Protein ID

 BC091293 

Genbank Nucleotide ID

 AAH91293.1 

Protein Name

 39S ribosomal protein L41, mitochondrial 

Protein Synonyms/Alias

 L41mt; MRP-L41 

Gene Name

 Mrpl41 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	PAIEKDFKEGTFDAN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (By similarity). 

Sequence Annotation

  

Keyword

 Apoptosis; Cell cycle; Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006412; P:translation; ISS:UniProtKB. 

Interpro

 IPR019189; Ribosomal_L27/L41_mit. 

Pfam

 PF09809; MRP-L27 

SMART

  

PROSITE

  

PRINTS