CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000543
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydropyrimidinase-related protein 4 
Protein Synonyms/Alias
 DRP-4; Collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4 
Gene Name
 Dpysl4 
Gene Synonyms/Alias
 Crmp3; Ulip4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
345TAQKAVGKDNFTLIPubiquitination[1]
472AGRFIPRKTFPDFVYubiquitination[1]
511HEVMLPAKPGSGTQAubiquitination[1]
525ARASCSGKISVPPVRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MSFQGKKSIP RITSDRLLIK GGKIVNDDQS FHADLYVEDG LIKQIGENLI VPGGIKTIDA 60
HGLMVLPGGV DVHTRLQMPV MGMTPADDFC QGTKAALAGG TTMILDHVFP DAGVSLLAAY 120
EQWRERADSA ACCDYSLHVD IPRWHESTKE ELEALVRDKG VNSFLVFMAY KDRCQCTDGQ 180
IYEIFSLIRD LGAVAQVHAE NGDIVEEEQK RLLEQGITGP EGHVLSHPEE VEAEAVYRAV 240
TIAKQANCPL YVTKVMSKGA ADMVAQAKRR GVVVFGEPIT ASLGTDGSHY WSKNWAKAAA 300
FVTSPPINPD PTTADHLTSL LSSGDLQVTG SAHCTFTTAQ KAVGKDNFTL IPEGVNGIEE 360
RMSVVWEKCV ASGKMDENEF VAVTSTNAAK IFNFYPRKGR VAVGSDADLV IWNPRATKVF 420
SAKSHNLNVE YNIFEGVECR GVPTVVISQG RVVLEDGNLL VTPGAGRFIP RKTFPDFVYK 480
RIKARNRLAE IHGVPRGLYD GPVHEVMLPA KPGSGTQARA SCSGKISVPP VRNLHQSGFS 540
LSGSQADDHI ARRTAQKIMA PPGGRSNITS LS 572 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro. 
Interpro
 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS