CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027595
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 EH-domain containing 4 
Protein Synonyms/Alias
 Pincher; Protein Ehd4 
Gene Name
 Ehd4 
Gene Synonyms/Alias
 rCG_26704 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
165PGILSGEKQRISRGYubiquitination[1]
208DEFSEAIKAFRGQDDacetylation[2]
327EMPSMFGKENKKRELacetylation[2]
373LENYDFTKFHSLKPKacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MFSWMGRQAG GRERSGGMDA VQTVTGGLRS LYQRKVLPLE EAYRFHEFHS PALEDADFEN 60
KPMILLVGQY STGKTTFIRY LLEQDFPGMR IGPEPTTDSF IAVMYGETEG STPGNALVVD 120
PKKPFRKLSR FGNAFLNRFM CSQLPNQVLK SISIIDSPGI LSGEKQRISR GYDFCQVLQW 180
FAERVDRIIL LFDAHKLDIS DEFSEAIKAF RGQDDKIRVV LNKADQVDTQ QLMRVYGALM 240
WSLGKVINTP EVLRVYIGSF WAQPLQNTDN RRLFEAEAQD LFRDIQSLPQ KAAVRKLNDL 300
IKRARLAKVH AYIISYLKKE MPSMFGKENK KRELIFRLPE IYVQLQREYQ ISAGDFPEVK 360
AMQEQLENYD FTKFHSLKPK LIEAVDNMLT NKISSLMSLI SQEEMNMPTQ MVQGGAFDGT 420
TEGPFNQGYG EGAKEGADEE EWVVAKDKPV YDELFYTLSP INGKISGVNA KKEMVTSKLP 480
NSVLGKIWKL ADCDCDGMLD EEEFALAKHL IKIKLDGYEL PNSLPPHLVP PSHRKSLPKA 540
D 541 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0055038; C:recycling endosome membrane; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0071363; P:cellular response to growth factor stimulus; IDA:RGD.
 GO:0032456; P:endocytic recycling; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0006907; P:pinocytosis; IMP:RGD.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:RGD.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0030100; P:regulation of endocytosis; IMP:RGD. 
Interpro
 IPR001401; Dynamin_GTPase.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000261; EPS15_homology.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N 
SMART
 SM00027; EH 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50031; EH 
PRINTS