CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017504
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 614 
Protein Synonyms/Alias
  
Gene Name
 ZNF614 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99SPNQRLLKSVQQCNGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 79 KRAB.
 ZN_FING 205 227 C2H2-type 1; atypical.
 ZN_FING 257 281 C2H2-type 2; degenerate.
 ZN_FING 287 309 C2H2-type 3.
 ZN_FING 315 337 C2H2-type 4.
 ZN_FING 343 365 C2H2-type 5.
 ZN_FING 371 393 C2H2-type 6.
 ZN_FING 399 421 C2H2-type 7.
 ZN_FING 427 449 C2H2-type 8.
 ZN_FING 455 477 C2H2-type 9.
 ZN_FING 483 505 C2H2-type 10.
 ZN_FING 511 533 C2H2-type 11.
 ZN_FING 539 561 C2H2-type 12.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 585 AA 
Protein Sequence
MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ TSKPDVLSKL 60
AHGQEPWTTD AKIQNKNCPG IGKVDSHLQE HSPNQRLLKS VQQCNGQNTL RNIVHLSKTH 120
FPIVQNHDTF DLYRKNLKSS LSLINQKRRH GINNPVEFIG GEKTLLHGKH ERTHTKTRFS 180
ENAKCIHTKF QVFKHQRTQK IEKPHACIEC EQTFLRKSQL IYHENICIQE NPGSGQCEKL 240
SRSVLFTKHL KTNTTDKICI PNEYRKGSTV KSSLITHQQT HTEEKSYMCS ECGKGFTMKR 300
YLIAHQRTHS GEKPYVCKEC GKGFTVKSNL IVHQRTHTGE KPYICSECGK GFTMKRYLVV 360
HQRTHTGEKP YMCSECGKGF TVKSNLIVHQ RSHTGEKSYI CSECGKGFTV KRTLVIHQRT 420
HTGEKSYICN ECGKGFTTKR TLIIHQRTHT GEKPYECNEC GKAFSQKICL IQHERCHTGK 480
TPFVCTECGK SYSHKYGLIT HQRIHTGEKP YECNECGKAF TTKSVLNVHQ RTHTGERPYG 540
CSDCEKAFSH LSNLVKHKKM HTREMGRISQ VENSCNGESQ LLPYK 585 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS