CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034056
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dynactin subunit 1 
Protein Synonyms/Alias
  
Gene Name
 Dctn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96QVRDLEEKLETLRLKacetylation[1]
422PPETFDFKIKFAETKubiquitination[2]
484LMPRLICKAELIRKQacetylation[3]
1022KTSQLLEKLNQLSTHubiquitination[2]
1099SSAFLRAKEEQQDDTubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1142 AA 
Protein Sequence
MMRQAPTARK TTTRRPKPTR PASTGVAGPS SSLGPSGSAS AGELSSSEPS TPAQTPLAAP 60
IIPTPALTSP GAAPPLPSPS KEEEGLRAQV RDLEEKLETL RLKRSEDKAK LKELEKHKIQ 120
LEQVQEWKSK MQEQQADLQR RLKEARKEAK EALEAKERYM EEMADTADAI EMATLDKEMA 180
EERAESLQQE VEALKERVDE LTTDLEILKA EIEEKGSDGA ASSYQLKQLE EQNARLKDAL 240
VRMRDLSSSE KQEHVKLQKL MEKKNQELEV VRQQRERLQE ELSQAESTID ELKEQVDAAL 300
GAEEMVEMLT DRNLNLEEKV RELRETVGDL EAMNEMNDEL QENARETELE LREQLDMAGA 360
RVREAQKRVE AAQETVADYQ QTIKKYRQLT AHLQDVNREL TNQQEASVER QQQPPPETFD 420
FKIKFAETKA HAKAIEMELR QMEVAQANRH MSLLTAFMPD SFLRPGGDHD CVLVLLLMPR 480
LICKAELIRK QAQEKFDLSE NCSERPGLRG AAGEQLSFAA GLVYSLSLLQ ATLHRYEHAL 540
SQCSVDVYKK VGSLYPEMSA HERSLDFLIE LLHKDQLDET VNVEPLTKAI KYYQHLYSIH 600
LAEQPEDSTM QLADHIKFTQ SALDCMGVEV GRLRAFLQGG QEATDIALLL RDLETSCSDT 660
RQFCKKIRRR MPGTDAPGIP AALAFGSQVS DTLLDCRKHL TWVVAVLQEV AAAAAQLIAP 720
LAENEGLPVA ALEELAFKAS EQIYGSPSSS PYECLRQSCT ILISTMNKLA TAMQEGEYDA 780
ERPPSKPPPV ELRAAALRAE ITDAEGLGLK LEDRETVIKE LKKSLKIKGE ELSEANVRLS 840
LLEKKLDSAA KDADERIEKV QTRLDETQTL LRKKEKDFEE TMDALQADID QLEAEKAELK 900
QRLNSQSKRT IEGLRGPPPS GIATLVSGIA GGGAPGQAPG ALPGPGLVKD SPLLLQQISA 960
MRLHISQLQH ENSILRGAQM KASLAALPPL HVAKLSLPPH EGPGGNLVAG ALYRKTSQLL 1020
EKLNQLSTHT HVVDITRSSP AAKSPSAQLM EQVAQLKSLS DTIEKLKDEV LKETVTQRPG 1080
ATVPTDFATF PSSAFLRAKE EQQDDTVYMG KVTFSCAAGL GQRHRLVLTQ EQLHQLHSRL 1140
IS 1142 
Gene Ontology
 GO:0031252; C:cell leading edge; IDA:MGI. 
Interpro
 IPR022157; Dynactin. 
Pfam
 PF12455; Dynactin 
SMART
  
PROSITE
  
PRINTS