CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008028
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Extracellular calcium-sensing receptor 
Protein Synonyms/Alias
 CaSR; Parathyroid cell calcium-sensing receptor; PCaR1 
Gene Name
 Casr 
Gene Synonyms/Alias
 Gprc2a; Pcar1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
882STAAHAFKVAARATLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system. 
Sequence Annotation
 REGION 880 900 Interaction with RNF19A (By similarity).
 CARBOHYD 90 90 N-linked (GlcNAc...) (Potential).
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 CARBOHYD 261 261 N-linked (GlcNAc...) (Potential).
 CARBOHYD 287 287 N-linked (GlcNAc...) (Potential).
 CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
 CARBOHYD 446 446 N-linked (GlcNAc...) (Potential).
 CARBOHYD 468 468 N-linked (GlcNAc...) (Potential).
 CARBOHYD 488 488 N-linked (GlcNAc...) (Potential).
 CARBOHYD 541 541 N-linked (GlcNAc...) (Potential).
 CARBOHYD 594 594 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1079 AA 
Protein Sequence
MASYSCCLAL LALAWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD LKSRPESVEC 60
IRYNFRGFRW LQAMIFAIEE INSSPSLLPN MTLGYRIFDT CNTVSKALEA TLSFVAQNKI 120
DSLNLDEFCN CSEHIPSTIA VVGATGSGVS TAVANLLGLF YIPQVSYASS SRLLSNKNQY 180
KSFLRTIPND EHQATAMADI IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS 240
ELISQYSDEE EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA 300
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE FWEETFNCHL 360
QEGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN INSVETPYMD YEHLRISYNV 420
YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD 480
ECGDLVGNYS IINWHLSPED GSIVFKEVGY YNVYAKKGER LFINEEKILW SGFSREVPFS 540
NCSRDCQAGT RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA 600
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL SYLLLFSLLC 660
CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN RVLLVFEAKI PTSFHRKWWG 720
LNLQFLLVFL CTFMQILICI IWLYTAPPSS YRNHELEDEI IFITCHEGSL MALGSLIGYT 780
CLLAAICFFF AFKSRKLPEN FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA 840
ILAASFGLLA CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS 900
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLSLTQ QEQQQQPLTL HPQQQQQPQQ 960
PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE AQRSNDTLGR HQALLPLQCA 1020
DADSEMTIQE TGLQGPMVGD HQPEMESSDE MSPALVMSTS RSFVISGGGS SVTENVLHS 1079 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0043679; C:axon terminus; IDA:RGD.
 GO:0016323; C:basolateral plasma membrane; IDA:RGD.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005509; F:calcium ion binding; IDA:RGD.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0004930; F:G-protein coupled receptor activity; IMP:RGD.
 GO:0000287; F:magnesium ion binding; IDA:RGD.
 GO:0019808; F:polyamine binding; IDA:RGD.
 GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IMP:RGD.
 GO:0006915; P:apoptotic process; IEP:RGD.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:RGD.
 GO:0006816; P:calcium ion transport; IMP:RGD.
 GO:0006874; P:cellular calcium ion homeostasis; IDA:RGD.
 GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
 GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEP:RGD.
 GO:0071456; P:cellular response to hypoxia; IEP:RGD.
 GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEP:RGD.
 GO:1901653; P:cellular response to peptide; IEP:RGD.
 GO:0071305; P:cellular response to vitamin D; IEP:RGD.
 GO:0060613; P:fat pad development; IEP:RGD.
 GO:0007254; P:JNK cascade; IMP:RGD.
 GO:0001503; P:ossification; IMP:RGD.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IMP:RGD.
 GO:0032781; P:positive regulation of ATPase activity; IEA:Compara.
 GO:0090280; P:positive regulation of calcium ion import; IMP:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.
 GO:0050927; P:positive regulation of positive chemotaxis; IMP:RGD.
 GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
 GO:0051592; P:response to calcium ion; IEP:RGD.
 GO:0071774; P:response to fibroblast growth factor stimulus; IEP:RGD.
 GO:0002931; P:response to ischemia; IEP:RGD.
 GO:0042311; P:vasodilation; IMP:RGD. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR000337; GPCR_3.
 IPR011500; GPCR_3_9-Cys_dom.
 IPR017978; GPCR_3_C.
 IPR017979; GPCR_3_CS. 
Pfam
 PF00003; 7tm_3
 PF01094; ANF_receptor
 PF07562; NCD3G 
SMART
  
PROSITE
 PS00979; G_PROTEIN_RECEP_F3_1
 PS00980; G_PROTEIN_RECEP_F3_2
 PS00981; G_PROTEIN_RECEP_F3_3
 PS50259; G_PROTEIN_RECEP_F3_4 
PRINTS
 PR00248; GPCRMGR.