CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014991
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exocyst complex component 3 
Protein Synonyms/Alias
 Exocyst complex component Sec6 
Gene Name
 Exoc3 
Gene Synonyms/Alias
 Sec6l1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
38QRPDQLDKVEQYRRRacetylation[1]
154ALLQAHRKLMDLECSubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (By similarity). 
Sequence Annotation
 MOD_RES 38 38 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Exocytosis; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 755 AA 
Protein Sequence
MCKDSACFLT MKETDLEAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK ASVEARLKAA 60
IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI NTIESLKDVK DAVVQHSQLA 120
AAVENLKNIF SVPEIVRETQ DLIEQGALLQ AHRKLMDLEC SRDGLMCEQY RMDSGNKRDM 180
TLIHGYFGST QGLSDELAKQ LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK 240
KQTGFVPPGR PKNWKEKMFA ILDRTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL 300
IVAKNLMVQC FPPHYEIFKN LLSMYHQALS TRMQDLASED LEANEIVSLL TWVLNTYTSA 360
EMMGNVELAP EVDVSALEPL LSPNIVSELL DTYMSTLTSN IIAWLRKALE TDKKDWSKET 420
EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA QISEDLKTKV LVLCLQQMNS FLSRYKDEAQ 480
LYKEEHLRNR QHPHCYVQYM IAIINNCQTF KESIISLKRK YLKTEAEEGL CLSQPSMDGI 540
LDAIAKEGCS SLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY 600
KKRMTAEAHR RVVVEYLRAV MQKRISFRSA EERKEGAEKM VREAEQLRFL FRKLASGFGE 660
DADGHCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD DHIGALLALR GDASRDMKQT 720
IMETLEQGPM QASPNYVPIF KEIVVPSLNV AKLLK 755 
Gene Ontology
 GO:0000145; C:exocyst; IEA:InterPro.
 GO:0030667; C:secretory granule membrane; TAS:Reactome.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR010326; Sec6. 
Pfam
 PF06046; Sec6 
SMART
  
PROSITE
  
PRINTS