| Tag | Content |
|---|
| CPLM ID | CPLM-023048 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynactin subunit 4 |
Protein Synonyms/Alias | Dyn4; Dynactin subunit p62 |
Gene Name | DCTN4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 69 | RDVGMADKSVASGGW | ubiquitination | [1] | | 89 | PHTQRMNKLIEYYQQ | ubiquitination | [1] | | 100 | YYQQLAQKEKVERDR | ubiquitination | [1] | | 124 | MPLAFSDKYGLGTRL | ubiquitination | [1] | | 149 | TLAGLSLKEGEDQKE | ubiquitination | [1] | | 313 | KELVLAGKDAAAEYD | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine.
MOD_RES 407 407 Phosphothreonine (By similarity). |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 460 AA |
Protein Sequence | MPSAEAKLKK NRCANCFDCP GCMHTLSTRA TSISTQLPDD PAKTTMKKAY YLACGFCRWT 60
SRDVGMADKS VASGGWQEPE NPHTQRMNKL IEYYQQLAQK EKVERDRKKL ARRRNYMPLA 120
FSDKYGLGTR LQRPRAGASI STLAGLSLKE GEDQKEIKIE PAQAVDEVEP LPEDYYTRPV 180
NLTEVTTLQQ RLLQPDFQPV CASQLYPRHK HLLIKRSLRC RKCEHNLSKP EFNPTSIKFK 240
IQLVAVNYIP EVRIMSIPNL RYMKESQVLL TLTNPVENLT HVTLFECEEG DPDDINSTAK 300
VVVPPKELVL AGKDAAAEYD ELAEPQDFQD DPDIIAFRKA NKVGIFIKVT PQREEGEVTV 360
CFKMKHDFKN LAAPIRPIEE SDQGTEVIWL TQHVELSLGP LLP 403 |
Gene Ontology | GO:0005813; C:centrosome; IDA:UniProtKB. GO:0005829; C:cytosol; TAS:Reactome. GO:0005634; C:nucleus; TAS:ProtInc. GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |