| Tag | Content |
|---|
| CPLM ID | CPLM-005671 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Monoglyceride lipase |
Protein Synonyms/Alias | MGL; Monoacylglycerol hydrolase; MAG hydrolase; MGH; Monoacylglycerol lipase; MAG lipase; MAGL; Serine hydrolase YJU3 |
Gene Name | YJU3 |
Gene Synonyms/Alias | YKL094W; YKL441 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 241 | QKNFAKDKPVIIMHG | ubiquitination | [1] | | 312 | KHTTTEAKP****** | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short- lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA). |
Sequence Annotation | ACT_SITE 123 123 Nucleophile (By similarity).
ACT_SITE 251 251 Charge relay system (By similarity).
ACT_SITE 281 281 Charge relay system (By similarity). |
Keyword | Complete proteome; Cytoplasm; Endoplasmic reticulum; Hydrolase; Lipid droplet; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 313 AA |
Protein Sequence | MAPYPYKVQT TVPELQYENF DGAKFGYMFW PVQNGTNEVR GRVLLIHGFG EYTKIQFRLM 60
DHLSLNGYES FTFDQRGAGV TSPGRSKGVT DEYHVFNDLE HFVEKNLSEC KAKGIPLFMW 120
GHSMGGGICL NYACQGKHKN EISGYIGSGP LIILHPHTMY NKPTQIIAPL LAKFLPRVRI 180
DTGLDLKGIT SDKAYRAFLG SDPMSVPLYG SFRQIHDFMQ RGAKLYKNEN NYIQKNFAKD 240
KPVIIMHGQD DTINDPKGSE KFIQDCPSAD KELKLYPGAR HSIFSLETDK VFNTVFNDMK 300
QWLDKHTTTE AKP 313 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005811; C:lipid particle; IDA:SGD. GO:0005741; C:mitochondrial outer membrane; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0047372; F:acylglycerol lipase activity; IMP:SGD. GO:0017171; F:serine hydrolase activity; ISM:SGD. GO:0019433; P:triglyceride catabolic process; IEA:UniProtKB-UniPathway. GO:0006641; P:triglyceride metabolic process; IMP:SGD. |
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Pfam | |
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PRINTS | |