| Tag | Content |
|---|
| CPLM ID | CPLM-015684 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 22 member 18 |
Protein Synonyms/Alias | Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Multi-membrane-spanning polyspecific transporter; Organic cation transporter-like protein 2; ORCTL-2 |
Gene Name | Slc22a18 |
Gene Synonyms/Alias | Impt1; Itm; Orctl2; Tssc5 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 204 | SAPQGGTKASVFDLK | ubiquitination | [1] | | 211 | KASVFDLKAITRLLL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). |
Sequence Annotation | |
Keyword | Cell membrane; Complete proteome; Ion transport; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 406 AA |
Protein Sequence | MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT TFGVLQLLGG 60
PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG VFLLFASRIP SALMHTLPAA 120
QMVITDLTAP TERPAALGRL GLCFGIGIIF GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV 180
LSFTCVPATT KEASVQSAPQ GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL 240
VMFSIISMDF FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV 300
GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL SASVQPLTRT 360
LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ KGEKAR 406 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; ISS:MGI. GO:0005635; C:nuclear envelope; IEA:Compara. GO:0015238; F:drug transmembrane transporter activity; IEA:Compara. GO:0008514; F:organic anion transmembrane transporter activity; TAS:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |