| Tag | Content |
|---|
| CPLM ID | CPLM-016293 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nitrilase homolog 1 |
Protein Synonyms/Alias | |
Gene Name | NIT1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 77 | QVTSTPDKQQNFKTC | ubiquitination | [1] | | 125 | LSEPLGGKLLEEYTQ | ubiquitination | [1] | | 158 | QDWEQTQKIYNCHVL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). |
Sequence Annotation | DOMAIN 47 320 CN hydrolase.
ACT_SITE 86 86 Proton acceptor (Potential).
ACT_SITE 161 161 By similarity.
ACT_SITE 203 203 Nucleophile (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Mitochondrion; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 327 AA |
Protein Sequence | MVLAISSCWA SSPGLLTDSC PFCVLDSGYL NSQYFVLSPG RTYSLSRRPR PRAMAISSSS 60
CELPLVAVCQ VTSTPDKQQN FKTCAELVRE AARLGACLAF LPEAFDFIAR DPAETLHLSE 120
PLGGKLLEEY TQLARECGLW LSLGGFHERG QDWEQTQKIY NCHVLLNSKG AVVATYRKTH 180
LCDVEIPGQG PMCESNSTMP GPSLESPVST PAGKIGLAVC YDMRFPELSL ALAQAGAEIL 240
TYPSAFGSIT GPAHWEVLLR ARAIETQCYV VAAAQCGRHH EKRASYGHSM VVDPWGTVVA 300
RCSEGPGLCL ARIDLNYLRQ LRRHLPVFQH RRPDLYGNLG HPLSDLTSVS LDLPLPPPPC 360
HYELVLM 367 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0000257; F:nitrilase activity; TAS:ProtInc. GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |