CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031229
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Annexin 
Protein Synonyms/Alias
  
Gene Name
 ANXA7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47EILRKAMKGFGTDEQubiquitination[1, 2, 3, 4]
72NDQRQKIKAAFKTSYubiquitination[2]
76QKIKAAFKTSYGKDLubiquitination[2, 4]
81AFKTSYGKDLIKDLKacetylation[5]
81AFKTSYGKDLIKDLKubiquitination[2]
85SYGKDLIKDLKSELSubiquitination[1, 2, 4]
157EFGRDLEKDIRSDTSubiquitination[2]
278ERLYYAMKGAGTDDSubiquitination[1, 2, 3, 4, 6, 7]
303EIDLVQIKQMFAQMYubiquitination[6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
MPSQYPGGQP TYPSQPATVT QVTQGTIRPA ANFDAIRDAE ILRKAMKGFG TDEQAIVDVV 60
ANRSNDQRQK IKAAFKTSYG KDLIKDLKSE LSGNMEELIL ALFMPPTYYD AWSLRKAMQG 120
AGTQERVLIE ILCTRTNQEI REIVRCYQSE FGRDLEKDIR SDTSGHFERL LVSMCQGNRD 180
ENQSINHQMA QEDAQRLYQA GEGRLGTDES CFNMILATRS FPQLRATMEA YSRMANRDLL 240
SSVSREFSGY VESGLKTILQ CALNRPAFFA ERLYYAMKGA GTDDSTLVRI VVTRSEIDLV 300
QIKQMFAQMY QKTLGTMIAG DTSGDYRRLL LAIVGQ 336 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR013286; AnnexinVII. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR01871; ANNEXINVII.