| Tag | Content |
|---|
| CPLM ID | CPLM-017262 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DCC-interacting protein 13-alpha |
Protein Synonyms/Alias | Dip13-alpha; Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 |
Gene Name | Appl1 |
Gene Synonyms/Alias | Dip13a; Kiaa1428 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 63 | AATHLTSKLLKEYEK | ubiquitination | [1] | | 66 | HLTSKLLKEYEKQRF | ubiquitination | [1] | | 70 | KLLKEYEKQRFPLGG | ubiquitination | [1] | | 512 | FLGSMEVKSDDHPDV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity). |
Sequence Annotation | DOMAIN 277 375 PH.
DOMAIN 495 655 PID.
REGION 1 428 Required for RAB5A binding (By
MOTIF 403 414 F&H (By similarity).
MOD_RES 399 399 Phosphothreonine (By similarity).
MOD_RES 401 401 Phosphoserine.
MOD_RES 410 410 Phosphoserine; by PKA (By similarity). |
Keyword | Cell cycle; Coiled coil; Complete proteome; Endosome; Membrane; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 707 AA |
Protein Sequence | MPGIDKLPIE ETLEDSPQTR SLLGVFEEDA TAISNYMNQL YQAMHRIYDA QNELSAATHL 60
TSKLLKEYEK QRFPLGGDDE VMSSTLQQFS KVIDELSSCH AVLSTQLADA MMFPISQFKE 120
RDLKEILTLK EVFQIASNDH DAAINRYSRL SKKRENDKVK YEVTEDVYTS RKKQHQTMMH 180
YFCALNTLQY KKKIALLEPL LGYMQAQISF FKMGSENLNG QLEEFLANIG TSVQNVRREM 240
DGDVETMQQT IEDLEVASDP LYLPDPDPTK FPINRNLTRK AGYLNARNKT GLVSSTWDRQ 300
FYFTQGGNLM SQARGDVAGG LAMDIDNCSV MAVDCEDRRY CFQITSFDGK KSSILQAESK 360
KDHEEWICTI NNISKQIYLS ENPEETAARV NQSALEAVTP SPSFQQRHES LRPGGQSRPP 420
TARTSSSGSL GSESTNLAAL SLDSLVAPDT PIQFDIISPV CEDQPGQAKA FGQGGRRTNP 480
FGESGGSTKS ETEDSILHQL FIVRFLGSME VKSDDHPDVV YETMRQILAA RAIHNIFRMT 540
ESHLLVTCDC LKLIDPQTQV TRLTFPLPCV VLYATHQENK RLFGFVLRTS GGRSESNLSS 600
VCYIFESNNE GEKICDSVGL AKQIALHAEL DRRASEKQKE IERVKEKQQK ELSKQKQIEK 660
DLEEQSRLIA ASSRPNQAGS EGQLVLSSSQ SEESDLGEEG KKRESEA 707 |
Gene Ontology | GO:0005829; C:cytosol; IEA:Compara. GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0010008; C:endosome membrane; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0016581; C:NuRD complex; IEA:Compara. GO:0012506; C:vesicle membrane; IEA:Compara. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0008283; P:cell proliferation; ISS:UniProtKB. GO:0090003; P:regulation of establishment of protein localization to plasma membrane; IEA:Compara. GO:0046324; P:regulation of glucose import; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |