CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018708
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mannose-6-phosphate isomerase 
Protein Synonyms/Alias
 Phosphohexomutase; Phosphomannose isomerase; PMI 
Gene Name
 Mpi 
Gene Synonyms/Alias
 Mpi1; Pmi 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
203NCFSHLMKSEKKVVVacetylation[1]
412LLKITVPKDLLIFRAubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity). 
Sequence Annotation
 ACT_SITE 295 295 By similarity.
 METAL 110 110 Zinc (By similarity).
 METAL 112 112 Zinc (By similarity).
 METAL 137 137 Zinc (By similarity).
 METAL 276 276 Zinc (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Isomerase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW MGTHPRGDAK 60
ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV LSVDTALSIQ AHPNKELAEK 120
LHLQAPEHYP DANHKPEMAI ALTSFQGLCG FRPVEEIVTF MKKVPEFQLL IGDDATAQLK 180
ESVGGDTEAM ASALRNCFSH LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ 240
LHQQHPGDIG CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP 300
KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM EVPSSVTEYK 360
VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA NESVLLKITV PKDLLIFRAC 420
CLL 423 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004476; F:mannose-6-phosphate isomerase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006013; P:mannose metabolic process; IC:MGI. 
Interpro
 IPR001250; Man6P_Isoase-1.
 IPR016305; Mannose-6-P_Isomerase.
 IPR018050; Pmannose_isomerase-type1_CS.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 
Pfam
 PF01238; PMI_typeI 
SMART
  
PROSITE
 PS00965; PMI_I_1
 PS00966; PMI_I_2 
PRINTS
 PR00714; MAN6PISMRASE.