CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016535
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial 
Protein Synonyms/Alias
 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; DHHB methyltransferase; DHHB-MT; DHHB-MTase; 3-demethylubiquinone-9 3-methyltransferase; Dihydroxyhexaprenylbenzoate methyltransferase 
Gene Name
 Coq3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
144SASHHPGKPLSGMKIacetylation[1]
150GKPLSGMKILDVGCGacetylation[1, 2]
197SFDPVLDKRIQYKVCacetylation[1, 2, 3]
284KGTHTWEKFVSPEKLacetylation[3]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Mitochondrion; Reference proteome; S-adenosyl-L-methionine; Transferase; Transit peptide; Ubiquinone biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 370 AA 
Protein Sequence
MWRGGRLGSR GVRLLETLGF GCPSAVAQPP RLTSRSAYSG TQLTRNLQIK PWELGEHGTM 60
CFRSYRMALS CLSRVKTYRT PWKRLYSTSQ TTVDSREVKN FQALAHTWWD EYGKFAPLHS 120
MNDLRVPFIR DNLLKTSASH HPGKPLSGMK ILDVGCGGGL LTEPLGRLGA SVVGIDPVAE 180
NIKIAQHHKS FDPVLDKRIQ YKVCSLEEAV DESAECFDAV VASEVVEHVS HLEMFIQCCY 240
QVLKPGGSLF ITTVNKTQLS YALGIVFAEQ IAGIVPKGTH TWEKFVSPEK LESILEPNGL 300
SVETVAGLVY NPFSGYWHWS ENTSLNYAAH AVRSRAQEHQ EPAESALKGE TGALHANTSG 360
SPSVREEQRT 370 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:InterPro.
 GO:0008689; F:3-demethylubiquinone-9 3-O-methyltransferase activity; IEA:EC.
 GO:0004395; F:hexaprenyldihydroxybenzoate methyltransferase activity; IEA:EC.
 GO:0006071; P:glycerol metabolic process; IEA:Compara.
 GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR010233; UbiG_MeTrfase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS