| Tag | Content |
|---|
| CPLM ID | CPLM-013953 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coiled-coil and C2 domain-containing protein 1B |
Protein Synonyms/Alias | Five prime repressor element under dual repression-binding protein 2; FRE under dual repression-binding protein 2; Freud-2 |
Gene Name | CC2D1B |
Gene Synonyms/Alias | KIAA1836 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 747 | KSKTAVVKNTNSPEF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. |
Sequence Annotation | DOMAIN 686 799 C2. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 858 AA |
Protein Sequence | MMPGPRPRKG PQARGQGVAA AKQMGLFMEF GPEDMLLGMD EAEDDEDLEA ELLALTGEAQ 60
TTGKKPAPKG QAPLPMAHIE KLAADCMRDV EEEEEEEGLE EDAELLTELQ EVLGVDEETE 120
PLDGDEVADP GGSEEENGLE DTEPPVQTAV LTASAPAAQA GASQGLHALL EERIHNYREA 180
AASAKEAGEA AKARRCERGL KTLESQLASV RRGRKINEDE IPPPVALGKR PLAPQEPANR 240
SPETDPPAPP ALESDNPSQP ETSLPGISAQ PVSDLDPDPR ALLSSRQREY KVAALSAKRA 300
GELDRARELM RIGKRFGAVL EALEKGQPVD LSAMPPAPED LKPQQASQAP TAPSVIPPAV 360
ERVQPVMAPD VPATPVAPTE SQTVLDALQQ RLNKYREAGI QARSGGDERK ARMHERIAKQ 420
YQDAIRAHRA GRKVNFAELP VPPGFPPIPG LESTMGVEED AVAATLAAAE KLASAEDSAP 480
ADKDEDEPPG HLQGEPPAQA PVAKKPARPT VPSSQRLPEP RASSSKESPS PSVREQLALL 540
EARKLQYQRA ALQAKRSQDL EQAKAYLRVA KWLEAQIIQA RSGRPVDLSK VPSPLTDEEG 600
DFILIHHEDL RLSQKAEEVY AQLQKMLLEQ QEKCLLFSKQ FMHQGNVAET TRFEKLAQDR 660
KKQLEILQLA QAQGLDPPTH HFELKTFQTV RIFSELNSTE MHLIIVRGMN LPAPPGVTPD 720
DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFDQLFKL NINRNHRGFK RVIQSKGIKF 780
EIFHKGSFFR SDKLVGTAHL KLERLENECE IREIVEVLDG RKPTGGKLEV KVRLREPLSG 840
QDVQMVTENW LVLEPRGL 858 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara. GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |