| Tag | Content |
|---|
| CPLM ID | CPLM-018224 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Importin-4 |
Protein Synonyms/Alias | Imp4; Importin-4a; Imp4a; Ran-binding protein 4; RanBP4 |
Gene Name | Ipo4 |
Gene Synonyms/Alias | Imp4a; Ranbp4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 205 | LARMLVPKVVTALRT | ubiquitination | [1] | | 762 | PAYMQAVKVERERPV | ubiquitination | [1] | | 977 | LMASPVGKTEPQVLA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains. |
Sequence Annotation | DOMAIN 24 90 Importin N-terminal.
REPEAT 348 385 HEAT 1.
REPEAT 390 427 HEAT 2.
REPEAT 431 471 HEAT 3.
REPEAT 475 513 HEAT 4.
REPEAT 896 933 HEAT 5.
REPEAT 937 975 HEAT 6.
MOD_RES 1 1 N-acetylmethionine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1082 AA |
Protein Sequence | MEPAGLEQIL KELLLPDTER IRRATEQLQT ILRDPAALPA LFDLLATATD SQIRQFAAVL 60
TRRRLNNRWR RLAPEQRESL KSLVLTALQK ETVHSVSVSL AQLSATIFRK EGLQGWPQFM 120
NLLQHSTHSS HSPEKEVGLL LLSVVVSSQP EAFHAHQHEL LQLLNETLSD VSFPGVLFYS 180
LRTLTAIARY VRPDDVSLAR MLVPKVVTAL RTLIPLDEVK ACEALEALDE MLETELPIIN 240
PHLSEVLTFC LEVAKNVALG EPLRVRVLCC LTFLVKVKSK ALLKNRLVPP LLHALFPLMA 300
AEPPMGQLDP EDQDSDDDDL EIGLMGETPK HFAVQVVDML ALHLPPEKLC PHVMPMLEEA 360
LRSEDPYQRK AGFLVLAVLS DGAGDHIRQR LLYPLLQIVC KGLDDPSQIV RNAALFALGQ 420
FSENLQPHIS SYSEEVMPLL LSYLKSVPMG NTHHLAKACY ALENFVENLG PKVQPYLPEL 480
MECMLQPLKN PSKARTKELA VSAIGAIATA AQDSLLPYFP TIMDLLREFL LTGHEDFHLV 540
QIQSLETLGV LARALGESMK PLAEECCQLG LGLCIHIDDP DVRRCTYSLF AALSGLMGEG 600
LGPYLPQITT LMLLSLRSTE GIVPQYDGIS SFLLFDDDSE AEEEEELMDE DMEEEGDDSE 660
ISGYSVENAF FDEKEDTCTA LGEISMNTCV AFLPFMDATF DEVYKLLECP HMNVRKSAYE 720
ALGQFCCALH KASQRSSSDP SSSPVLQTSL ARVMPAYMQA VKVERERPVV MAVLESLTGV 780
LRTCGSLALQ PPGRLSELCN VLKAVLQKKT ACQDAEEDDD EDDDQAEYDA MLLEHAGEAI 840
PVLAATAGGH AFAPFFATFL PLLLCKTKQS CTVAEKSFAV GTLAESIQGL GTASAQFVSR 900
LFPVLLNNAR EADPEVRSNA IFGLGVLAEH GGCPAQDHFP KLLGLLLPLL ARERHDRVRD 960
NICGALARVL MASPVGKTEP QVLATLLRAL PLKEDMEEWL TIGHLFSFLH QNNPEQVVDV 1020
ASELLRICSL ILPDNRIPPD TKAALLLLLT FLAKQHTDSF HTALGSLPND KAQELQAMMG 1080
LT 1082 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005643; C:nuclear pore; IEA:InterPro. GO:0008565; F:protein transporter activity; IEA:InterPro. GO:0006610; P:ribosomal protein import into nucleus; ISA:MGI. GO:0042254; P:ribosome biogenesis; ISA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |