CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041656
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-2 
Protein Synonyms/Alias
 RCG49564, isoform CRA_a 
Gene Name
 Cdh2 
Gene Synonyms/Alias
 rCG_49564 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
756RDKERQAKQLLIDPEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Cadherins are calcium dependent cell adhesion proteins (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Cell membrane; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 906 AA 
Protein Sequence
MCRIAGAPRT LLPLLAALLQ ASLEASGELA LCKTGFPEAV YSAVLPKDVH EGQPLLNVKF 60
SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLSAEQA KFLIYAQDKE TQEKWQVAVN 120
LSLEPSLTEE PMKEPHEIEE IVFPRQLAKH SGALQRQKRD WVIPPINLPE NSRGPFPQEL 180
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAAY 420
RISGGDPTGR FAILTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP 540
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPEPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660
FAQLNLKIKF LEAGIYEVPI VITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780
EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 900
YGGGDD 906 
Gene Ontology
 GO:0016342; C:catenin complex; IEA:Compara.
 GO:0005916; C:fascia adherens; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0048514; P:blood vessel morphogenesis; IEA:Compara.
 GO:0016339; P:calcium-dependent cell-cell adhesion; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara.
 GO:0051146; P:striated muscle cell differentiation; IEA:Compara. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR009124; Cadherin/Desmocollin.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01820; DESMOCOLLIN.