CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003883
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 2, facilitated glucose transporter member 1 
Protein Synonyms/Alias
 Glucose transporter type 1, erythrocyte/brain; GLUT-1 
Gene Name
 Slc2a1 
Gene Synonyms/Alias
 Glut-1; Glut1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
245TRDLQEMKEEGRQMMubiquitination[1]
477GGASQSDKTPEELFHubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. 
Sequence Annotation
 REGION 279 281 Defines substrate specificity (By
 MOD_RES 234 234 Phosphothreonine (By similarity).
 MOD_RES 478 478 Phosphothreonine (By similarity).
 MOD_RES 490 490 Phosphoserine (By similarity).
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MEPSSKKVTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWNH RYGESIPSTT 60
LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN LLAFVSAVLM GFSKLGKSFE 120
MLILGRFIIG VYCGLTTGFV PMYVGEVSPT ALRGALGTLH QLGIVVGILI AQVFGLDSIM 180
GNADLWPLLL SVIFIPALLQ CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD 240
LQEMKEEGRQ MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK 300
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL MTIALALLEQ 360
LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR PAAVAVAGFS NWTSNFIVGM 420
CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF KVPETKGRTF DEIASGFRQG GASQSDKTPE 480
ELFHPLGADS QV 492 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005901; C:caveola; IDA:RGD.
 GO:0005911; C:cell-cell junction; IDA:RGD.
 GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.
 GO:0001939; C:female pronucleus; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0055056; F:D-glucose transmembrane transporter activity; IDA:UniProtKB.
 GO:0033300; F:dehydroascorbic acid transporter activity; IDA:UniProtKB.
 GO:0043621; F:protein self-association; ISS:UniProtKB.
 GO:0005351; F:sugar:hydrogen symporter activity; TAS:RGD.
 GO:0042910; F:xenobiotic transporter activity; IDA:RGD.
 GO:0042149; P:cellular response to glucose starvation; IEA:Compara.
 GO:0006461; P:protein complex assembly; ISS:UniProtKB.
 GO:0006970; P:response to osmotic stress; IEP:RGD. 
Interpro
 IPR002439; Glu_transpt_1.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 
PRINTS
 PR01190; GLUCTRSPORT1.
 PR00171; SUGRTRNSPORT.