UniProt Accession

 PROF_YEAST; P07274; D6W2I0 

Genbank Protein ID

 M23369; Y00469; X90518; X94335; Z75030; BK006948 

Genbank Nucleotide ID

 AAA34861.1; CAA68532.1; CAA62128.1; CAA64041.1; CAA99321.1; DAA10896.1 

Protein Name

 Profilin 

Protein Synonyms/Alias

  

Gene Name

 PFY1 

Gene Synonyms/Alias

 PFY; PRF1; YOR122C; O3275; YOR3275C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
18	IGTGKVDKAVIYSRA	acetylation	[1]
93	GVVCVRTKQTVIIAH	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. 

Sequence Annotation

  

Keyword

 3D-structure; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0019897; C:extrinsic to plasma membrane; IDA:SGD.
 GO:0003785; F:actin monomer binding; IDA:SGD.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IMP:SGD.
 GO:0070064; F:proline-rich region binding; IDA:SGD.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0046907; P:intracellular transport; IGI:SGD.
 GO:0090338; P:positive regulation of formin-nucleated actin cable assembly; IDA:SGD.
 GO:0042989; P:sequestering of actin monomers; IDA:SGD. 

Interpro

 IPR027310; Profilin_CS.
 IPR005455; Profilin_eukaryotes/bac. 

Pfam

 PF00235; Profilin 

SMART

 SM00392; PROF 

PROSITE

 PS00414; PROFILIN 

PRINTS

 PR00392; PROFILIN.
 PR01640; PROFILINPLNT.