CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022262
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SAFB-like transcription modulator 
Protein Synonyms/Alias
 Modulator of estrogen-induced transcription 
Gene Name
 SLTM 
Gene Synonyms/Alias
 MET 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
401NTKAADLKNLFGKYGacetylation[1]
406DLKNLFGKYGKVLSAacetylation[1]
609KEILPFEKMKEQRLRubiquitination[2]
1024RGSGSGFKPFKGGPPacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis (By similarity). 
Sequence Annotation
 DOMAIN 22 56 SAP.
 DOMAIN 384 462 RRM.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 97 97 Phosphoserine.
 MOD_RES 139 139 Phosphoserine (By similarity).
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 289 289 Phosphoserine.
 MOD_RES 401 401 N6-acetyllysine.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 550 550 Phosphoserine.
 MOD_RES 551 551 Phosphoserine.
 MOD_RES 553 553 Phosphoserine.
 MOD_RES 748 748 Phosphoserine.
 MOD_RES 800 800 Phosphoserine.
 MOD_RES 909 909 Phosphoserine.
 MOD_RES 944 944 Phosphoserine.
 MOD_RES 1002 1002 Phosphoserine.
 MOD_RES 1014 1014 Phosphoserine.
 MOD_RES 1019 1019 Phosphoserine.
 MOD_RES 1021 1021 Phosphoserine.
 MOD_RES 1024 1024 N6-acetyllysine.  
Keyword
 Acetylation; Apoptosis; Coiled coil; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1034 AA 
Protein Sequence
MAAATGAVAA SAASGQAEGK KITDLRVIDL KSELKRRNLD ITGVKTVLIS RLKQAIEEEG 60
GDPDNIELTV STDTPNKKPT KGKGKKHEAD ELSGDASVED DAFIKDCELE NQEAHEQDGN 120
DELKDSEEFG ENEEENVHSK ELLSAEENKR AHELIEAEGI EDIEKEDIES QEIEAQEGED 180
DTFLTAQDGE EEENEKDIAG SGDGTQEVSK PLPSEGSLAE ADHTAHEEME AHTTVKEAED 240
DNISVTIQAE DAITLDFDGD DLLETGKNVK ITDSEASKPK DGQDAIAQSP EKESKDYEMN 300
ANHKDGKKED CVKGDPVEKE ARESSKKAES GDKEKDTLKK GPSSTGASGQ AKSSSKESKD 360
SKTSSKDDKG STSSTSGSSG SSTKNIWVSG LSSNTKAADL KNLFGKYGKV LSAKVVTNAR 420
SPGAKCYGIV TMSSSTEVSR CIAHLHRTEL HGQLISVEKV KGDPSKKEMK KENDEKSSSR 480
SSGDKKNTSD RSSKTQASVK KEEKRSSEKS EKKESKDTKK IEGKDEKNDN GASGQTSESI 540
KKSEEKKRIS SKSPGHMVIL DQTKGDHCRP SRRGRYEKIH GRSKEKERAS LDKKRDKDYR 600
RKEILPFEKM KEQRLREHLV RFERLRRAME LRRRREIAER ERRERERIRI IREREERERL 660
QRERERLEIE RQKLERERME RERLERERIR IEQERRKEAE RIAREREELR RQQQQLRYEQ 720
EKRNSLKRPR DVDHRRDDPY WSENKKLSLD TDARFGHGSD YSRQQNRFND FDHRERGRFP 780
ESSAVQSSSF ERRDRFVGQS EGKKARPTAR REDPSFERYP KNFSDSRRNE PPPPRNELRE 840
SDRREVRGER DERRTVIIHD RPDITHPRHP REAGPNPSRP TSWKSEGSMS TDKRETRVER 900
PERSGREVSG HSVRGAPPGN RSSASGYGSR EGDRGVITDR GGGSQHYPEE RHVVERHGRD 960
TSGPRKEWHG PPSQGPSYHD TRRMGDGRAG AGMITQHSSN ASPINRIVQI SGNSMPRGSG 1020
SGFKPFKGGP PRRF 1034 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR003034; SAP_dom. 
Pfam
 PF00076; RRM_1
 PF02037; SAP 
SMART
 SM00360; RRM
 SM00513; SAP 
PROSITE
 PS50102; RRM
 PS50800; SAP 
PRINTS