CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014850
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal recognition particle 54 kDa protein 
Protein Synonyms/Alias
 SRP54 
Gene Name
 Srp54 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
81MIQHAVFKELVKLVDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (By similarity). 
Sequence Annotation
 NP_BIND 108 115 GTP (By similarity).
 NP_BIND 190 194 GTP (By similarity).
 NP_BIND 248 251 GTP (By similarity).
 REGION 1 295 G-domain.
 REGION 296 504 M-domain.  
Keyword
 Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MVLADLGRKI TSALRSLSNA TIINEEVLNA MLKEVCTALL EADVNIKLVK QLRENVKSAI 60
DLEEMASGLN KRKMIQHAVF KELVKLVDPG VKAWTPTKGK QNVIMFVGLQ GSGKTTTCSK 120
LAYFYQRKGW KTCLICADTF RAGAFDQLKQ NATKARIPFY GSYTEMDPVI IASEGVEKFK 180
NENFEIIIVD TSGRHKQEDS LFEEMLQVSN AIQPDNIVYV MDASIGQACE AQAKAFKDKV 240
DVASVIVTKL DGHAKGGGAL SAVAATKSPI IFIGTGEHID DFEPFKTQPF ISKLLGMGDI 300
EGLIDKVNEL KLDDNEALIE KLKHGQFTLR DMYEQFQNIM KMGPFSQILG MIPGFGTDFM 360
SKGNEQESMA RLKKLMTIMD SMNDQELDST DGAKVFSKQP GRIQRVARGS GVSTRDVQEL 420
LTQYTKFAQM VKKMGGIKGL FKGGDMSKNV SQSQMAKLNQ QMAKMMDPRV LHHMGGMAGL 480
QSMMRQFQQG AAGNMKGMMG FNNM 504 
Gene Ontology
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:Compara.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0043021; F:ribonucleoprotein complex binding; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR027417; P-loop_NTPase.
 IPR013822; Signal_recog_particl_SRP54_hlx.
 IPR004125; Signal_recog_particle_SRP54_M.
 IPR022941; SRP54.
 IPR006325; SRP54_euk.
 IPR000897; SRP54_GTPase_dom. 
Pfam
 PF00448; SRP54
 PF02881; SRP54_N
 PF02978; SRP_SPB 
SMART
 SM00382; AAA
 SM00962; SRP54
 SM00963; SRP54_N 
PROSITE
 PS00300; SRP54 
PRINTS