CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038844
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium leak channel non-selective protein 
Protein Synonyms/Alias
  
Gene Name
 Nalcn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
648PQMVKISKLPSDFTVacetylation[1]
657PSDFTVPKIRESFMKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1736 AA 
Protein Sequence
MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT 60
FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV 120
SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS 180
VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGNVTWN SLAIPDTHCS PELEEGYQCP 240
PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEASSQE GWVFLMYRAI DSFPRWRSYF 300
YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGTRS STTSTATTQM FHEDAAGGWQ 360
LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVTVDVIV AASNYYKGEN FRRQYDEFYL 420
AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY HSQFTYFQVL 480
RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF 540
PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPLVAIYFI LYHLFATLIL LSLFVAVILD 600
NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP SDFTVPKIRE 660
SFMKQFIDRQ QQDTCCLFRI LPSTSSSSCD NPKRPTVEDN KYIDQKLRKS VFSIRARNLL 720
EKETAVTKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG SNSQRISRGK 780
SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH PYFDKPLFIV 840
GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW VMITVTICSC 900
ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF 960
IYLVSLIFLC WMPQNVPAES GAQLLMVLRC LRPLRIFKLV PQMRKVVREL FSGFKEIFLV 1020
SILLLTLMLV FASFGVQLFA GKLAKCNDPN IIRREDCNGI FRINVSVSKN LNLKLRPGEK 1080
KPGFWVPRVW ANPRNFNFDN VGNAMLALFE VLSLKGWVEV RDVIIHRVGP IHGIYIHVFV 1140
FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS RLKIAQPLHL PPRPDNDGFR 1200
AKMYDITQHP FFKRTIALLV LAQSVLLSVK WSVVITAPCS LVFKVFEYSF VLKVTMKIIA 1260
MSPAGFWQSR RNRYDLLVTS LGVVWVVLHF ALLNAYTYMM GACVIVFRFF SICGKHVTLK 1320
MLLLTVVVSM YKSFFIIVGM FLLLLCYAFA GVVLFGTVKY GENINRHANF SSAGKAITVL 1380
FRIVTGEDWN KIMHDCMVQP PFCTPDEFTY WATDCGNYAG ALMYFCSFYV IIAYIMLNLL 1440
VAIIVENFSL FYSTEEDQLL SYNDLRHFQI IWNMVDDKRE GVIPTFRVKF LLRLLRGRLE 1500
VDLDKDKLLF KHMCYEMERL HNGGDVTFHD VLSMLSYRSV DIRKSLQLEE LLAREQLEYT 1560
IEEEVAKQTI RMWLKKCLKR IRAKQQQSCS IIHSLRESQQ QELSRFLNPP SIETTQPSED 1620
TNANSQDHNT QPESSSQQQL LSPTLSDRGG SRQDAADTGK PQRKIGQWRL PSAPKPISHS 1680
VSSVNLRFGG RTTMKSVVCK MNPMPDTASC GSEVKKWWTR QLTVESDESG DDLLDI 1736 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005216; F:ion channel activity; IEA:InterPro. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom. 
Pfam
 PF00520; Ion_trans 
SMART
  
PROSITE
  
PRINTS