CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038163
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phenylalanine--tRNA ligase alpha subunit 
Protein Synonyms/Alias
  
Gene Name
 Farsa 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
150VQAGQAEKLAEKERNubiquitination[1]
187AFSTSVSKQEAELSPubiquitination[1]
208SWRDRPFKPYNFSARubiquitination[1]
315QGYKYTWKLEEARKNacetylation[2]
480IRELVGHKVNLQMVYacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MADNPVLELL LRRLEVADGG LDSAELATQL GVEHQAVVGA VKSLQALGEV IEAELRSTKC 60
WELTTEGEEI AREGSHEARV FRSIPLEGLV QSELMHLPSG KVGFSKAMSN KWIRVDKSAA 120
DGPRVFRVVD SIEDEVQKRL QLVQAGQAEK LAEKERNELR KRKLLTEVIL KTYWVSKGKA 180
FSTSVSKQEA ELSPEMISSG SWRDRPFKPY NFSARGVLPD SGHLHPLLKV RSQFRQIFLE 240
MGFTEMPTDN FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM GYVQRVKRTH 300
SQGGYGSQGY KYTWKLEEAR KNLLRTHTTA ASARALYQLA QKPFTPAKYF SIDRVFRNET 360
LDATHLAEFH QIEGVIADHG LTLGHLMGVL REFFTKLGIT QLRFKPAYNP YTEPSMEVFS 420
YHQGLKKWVE VGNSGVFRPE MLLPMGLPEN VSVIAWGLSL ERPTMIKYGI NNIRELVGHK 480
VNLQMVYDSP VCRLDIEPRS SKTQEAA 507 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
 GO:0000049; F:tRNA binding; IEA:InterPro.
 GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR006195; aa-tRNA-synth_II.
 IPR013196; HTH_11.
 IPR004529; Phe-tRNA-synth_IIc_asu.
 IPR002319; Phenylalanyl-tRNA_Synthase.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF08279; HTH_11
 PF01409; tRNA-synt_2d 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS