CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020987
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isochorismatase domain-containing protein 2B, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Isoc2b 
Gene Synonyms/Alias
 Isoc2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MGAAKASLGRIFacetylation[1]
5***MGAAKASLGRIFsuccinylation[1]
178DAAHPQFKEIQKILKacetylation[1, 2, 3]
178DAAHPQFKEIQKILKsuccinylation[1]
185KEIQKILKEPVTDIGacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 210 AA 
Protein Sequence
MGAAKASLGR IFPESSILFL CDMQEKLRDR ILYFPQIVSK AARMLKVAQM LEIPVLLTEH 60
YPQGLGPTVP ELGAQGLRTM SKTSFSMVPP LQQELDKLPQ LQSVLLCGIE TQGCILHTAL 120
DLLDRGLQVH VAVDACSSQS EMNRLVALAR MQQSGVFLST SEVLILQLVK DAAHPQFKEI 180
QKILKEPVTD IGLLGFFQGK KNSLLPNSRT 210 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003824; F:catalytic activity; IEA:InterPro. 
Interpro
 IPR000868; Isochorismatase-like. 
Pfam
 PF00857; Isochorismatase 
SMART
  
PROSITE
  
PRINTS