UniProt Accession

 GSTM5_MOUSE; P48774; Q545W5 

Genbank Protein ID

 U24428; AK002750; AK019317; AK028098; BC008206 

Genbank Nucleotide ID

 AAB04096.1; BAB22327.1; BAB31661.1; BAC25746.1; AAH08206.1 

Protein Name

 Glutathione S-transferase Mu 5 

Protein Synonyms/Alias

 Fibrous sheath component 2; Fsc2; GST class-mu 5 

Gene Name

 Gstm5 

Gene Synonyms/Alias

 Fsc2; Gstm3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
4	****MSSKSMVLGYW	ubiquitination	[1]
34	TDTSYEEKRYICGEA	ubiquitination	[1]
70	LPYLMDGKNKITQSN	ubiquitination	[1]
72	YLMDGKNKITQSNAI	ubiquitination	[1]
127	NSNHENLKPQYLEQL	ubiquitination	[1]
176	QNRIFEPKCLDEFPN	ubiquitination	[1]
208	LQSDRFFKMPINNKM	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 4 91 GST N-terminal.
 DOMAIN 93 211 GST C-terminal.
 REGION 10 11 Glutathione binding (By similarity).
 REGION 49 53 Glutathione binding (By similarity).
 REGION 62 63 Glutathione binding (By similarity).
 REGION 75 76 Glutathione binding (By similarity).
 BINDING 119 119 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043295; F:glutathione binding; IEA:Compara.
 GO:0004364; F:glutathione transferase activity; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0070458; P:cellular detoxification of nitrogen compound; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; ISS:UniProtKB.
 GO:0018916; P:nitrobenzene metabolic process; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0042178; P:xenobiotic catabolic process; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01267; GSTRNSFRASEM.