CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019192
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription elongation factor A protein-like 4 
Protein Synonyms/Alias
 TCEA-like protein 4; Transcription elongation factor S-II protein-like 4 
Gene Name
 TCEAL4 
Gene Synonyms/Alias
 NPD017 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
282KGLAHYLKEYKEAIHubiquitination[1, 2]
285AHYLKEYKEAIHDMNubiquitination[1, 2, 3, 4, 5]
318EKRKSKQKLGAFLWMubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 215 AA 
Protein Sequence
MPAGGQAPQL TPVIPAFWEA RGLPNSKGRD KVHICQCEEW KGHISYVERD ITTSEIKSLP 60
QVSVRAFHAA SGTLEWRKGN GYGRGKGWGW GRVESREAGP SVDRDGGLRV CCSQRSAKPE 120
KEEQPVQNPR RSVKDRKRRG NLDMEKLYSE NEGMASNQGK MENEEQPQDE RKPEVTCTLE 180
DKKLENEGKT ENKGKTGDEE MLKDKGKPES EGEAKEGKSE REGESEMEGG SEREGKPEIE 240
GKPESEGEPG SETRAAGKRP AEDDVPRKAK RKTNKGLAHY LKEYKEAIHD MNFSNEDMIR 300
EFDNMAKVQD EKRKSKQKLG AFLWMQRNLQ DPFYPRGPRE FRGGCRAPRR DIEDIPYV 358 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR021156; TF_A-like/BEX-like.
 IPR010370; TFA. 
Pfam
 PF04538; BEX 
SMART
  
PROSITE
  
PRINTS