CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011346
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CTD small phosphatase-like protein 2 
Protein Synonyms/Alias
 CTDSP-like 2 
Gene Name
 CTDSPL2 
Gene Synonyms/Alias
 HSPC058; HSPC129 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26RTARAKRKYSEVDDSacetylation[1]
57SSIKKFIKGSTPKEEacetylation[1]
125QHVKQNGKLEDNPSSubiquitination[2]
358SKKVYADKLLNILDPubiquitination[3, 4]
388CVQGNYIKDLNILGRubiquitination[2]
441KLIPFLEKLVELNEDubiquitination[2, 5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 Probable phosphatase (By similarity). 
Sequence Annotation
 DOMAIN 283 442 FCP1 homology.
 MOD_RES 26 26 N6-acetyllysine.
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 57 57 N6-acetyllysine.
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 86 86 Phosphothreonine.
 MOD_RES 104 104 Phosphoserine.
 MOD_RES 134 134 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Hydrolase; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MRLRTRKASQ QSNQIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS SIKKFIKGST 60
PKEERENPSK RSRIERDIDN NLITSTPRAG EKPNKQISRV RRKSQVNGEA GSYEMTNQHV 120
KQNGKLEDNP SSGSPPRTTL LGTIFSPVFN FFSPANKNGT SGSDSPGQAV EAEEIVKQLD 180
MEQVDEITTS TTTSTNGAAY SNQAVQVRPS LNNGLEEAEE TVNRDIPPLT APVTPDSGYS 240
SAHAEATYEE DWEVFDPYYF IKHVPPLTEE QLNRKPALPL KTRSTPEFSL VLDLDETLVH 300
CSLNELEDAA LTFPVLFQDV IYQVYVRLRP FFREFLERMS QMYEIILFTA SKKVYADKLL 360
NILDPKKQLV RHRLFREHCV CVQGNYIKDL NILGRDLSKT IIIDNSPQAF AYQLSNGIPI 420
ESWFMDKNDN ELLKLIPFLE KLVELNEDVR PHIRDRFRLH DLLPPD 466 
Gene Ontology
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
 GO:0016311; P:dephosphorylation; IEA:GOC. 
Interpro
 IPR011948; Dullard_phosphatase.
 IPR023214; HAD-like_dom.
 IPR004274; NIF. 
Pfam
 PF03031; NIF 
SMART
 SM00577; CPDc 
PROSITE
 PS50969; FCP1 
PRINTS