Tag | Content |
---|
CPLM ID | CPLM-005175 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-alpha-hydroxysteroid dehydrogenase |
Protein Synonyms/Alias | 3-alpha-HSD; Hydroxyprostaglandin dehydrogenase |
Gene Name | Akr1c9 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
---|
31 | TVPEKVAKDEVIKAT | acetylation | [1] | 36 | VAKDEVIKATKIAID | acetylation | [1] | 39 | DEVIKATKIAIDNGF | acetylation | [1] | 101 | LVRTCLEKTLKSTQL | acetylation | [1] | 201 | HLYLNQSKMLDYCKS | acetylation | [1] | 225 | TLGSSRDKTWVDQKS | acetylation | [1] | 246 | PVLCAIAKKYKQTPA | acetylation | [1] | 275 | LIRSFNAKRIKELTQ | acetylation | [1] | 309 | NFRYNNAKYFDDHPN | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Besides being a 3-alpha-hydroxysteroid dehydrogenase, the enzyme can accomplish diverse functions: as quinone reductase, as an aromatic alcohol dehydrogenase, as dihydrodiol dehydrogenase, and as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase. |
Sequence Annotation | NP_BIND 217 280 NADP. ACT_SITE 55 55 Proton donor. BINDING 117 117 Substrate. MOD_RES 1 1 Blocked amino end (Met). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 322 AA |
Protein Sequence | MDSISLRVAL NDGNFIPVLG FGTTVPEKVA KDEVIKATKI AIDNGFRHFD SAYLYEVEEE 60 VGQAIRSKIE DGTVKREDIF YTSKLWSTFH RPELVRTCLE KTLKSTQLDY VDLYIIHFPM 120 ALQPGDIFFP RDEHGKLLFE TVDICDTWEA MEKCKDAGLA KSIGVSNFNC RQLERILNKP 180 GLKYKPVCNQ VECHLYLNQS KMLDYCKSKD IILVSYCTLG SSRDKTWVDQ KSPVLLDDPV 240 LCAIAKKYKQ TPALVALRYQ LQRGVVPLIR SFNAKRIKEL TQVFEFQLAS EDMKALDGLN 300 RNFRYNNAKY FDDHPNHPFT DE 322 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0047026; F:androsterone dehydrogenase (A-specific) activity; IEA:EC. GO:0016229; F:steroid dehydrogenase activity; IMP:RGD. GO:0021766; P:hippocampus development; IEP:RGD. GO:0008202; P:steroid metabolic process; TAS:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |