CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SUMO-interacting motif-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 SIMC1 
Gene Synonyms/Alias
 C5orf25 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
401VMETPARKEISLSEPubiquitination[1]
410ISLSEPAKPGSAHVQubiquitination[1]
463TRENKGQKLEPIPHRubiquitination[1]
543QLHPANAKTVEWDWKubiquitination[2, 3]
550KTVEWDWKLLTYVMEacetylation[4]
605NMVLSCDKQPHNVRDubiquitination[1]
615HNVRDVIKWLVKAVTubiquitination[2]
619DVIKWLVKAVTEDGLubiquitination[1, 3]
643SSGTGILKASSSHPSubiquitination[1, 3]
657SSQPNLTKNTNQLIVubiquitination[1, 5]
804DLIIKRIKPKPQQGDubiquitination[1, 5]
806IIKRIKPKPQQGDDIubiquitination[1]
844LVPQLQDKVHLLKLLubiquitination[1, 3]
849QDKVHLLKLLLFYAAubiquitination[1]
867PDAEPFQKGWSGS**ubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 MOTIF 26 30 SUMO interaction motif 1 (SIM); mediates
 MOTIF 45 49 SUMO interaction motif 2 (SIM); mediates  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 872 AA 
Protein Sequence
MAPASASGED LRKLPTMAEV NGEQDFIDLT RETRPRTKDR SGLYVIDLTR AEGENRPIAT 60
LDLTLEPVTP SQKEPTSLQT CASLSGKAVM EGHVDRSSQP TARRIINSDP VDLDLVEENT 120
FVGPPPATSI SGGSVYPTEP NCSSATFTGN LSFLASLQLS SDVSSLSPTS NNSRSSSSSS 180
NQKAPLPCPQ QDVSRPPQAL PCPLRPLPCP PRASPCPPRA SSCPPRALSC PSQTMQCQLP 240
ALTHPPQEVP CPRQNIPGPP QDSLGLPQDV PGLPQSILHP QDVAYLQDMP RSPGDVPQSP 300
SDVSPSPDAP QSPGGMPHLP GDVLHSPGDM PHSSGDVTHS PRDIPHLPGD RPDFTQNDVQ 360
NRDMPMDISA LSSPSCSPSP QSETPLEKVP WLSVMETPAR KEISLSEPAK PGSAHVQSRT 420
PQGGLYNRPC LHRLKYFLRP PVHHLFFQTL IPDKDTRENK GQKLEPIPHR RLRMVTNTIE 480
ENFPLGTVQF LMDFVSPQHY PPREIVAHII QKILLSGSET VDVLKEAYML LMKIQQLHPA 540
NAKTVEWDWK LLTYVMEEEG QTLPGRVLFL RYVVQTLEDD FQQTLRRQRQ HLQQSIANMV 600
LSCDKQPHNV RDVIKWLVKA VTEDGLTQPP NGNQTSSGTG ILKASSSHPS SQPNLTKNTN 660
QLIVCQLQRM LSIAVEVDRT PTCSSNKIAE MMFGFVLDIP ERSQREMFFT TMESHLLRCK 720
VLEIIFLHSC ETPTRLPLSL AQALYFLNNS TSLLKCQSDK SQWQTWDELV EHLQFLLSSY 780
QHVLREHLRS SVIDRKDLII KRIKPKPQQG DDITVVDVEK QIEAFRSRLI QMLGEPLVPQ 840
LQDKVHLLKL LLFYAADLNP DAEPFQKGWS GS 872 
Gene Ontology
 GO:0032184; F:SUMO polymer binding; IDA:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS