| Tag | Content |
|---|
| CPLM ID | CPLM-016843 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tensin-like C1 domain-containing phosphatase |
Protein Synonyms/Alias | C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-2 |
Gene Name | Tenc1 |
Gene Synonyms/Alias | Tns2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 640 | YAEASVEKRRLCRSL | ubiquitination | [1] | | 660 | PYAPELGKPANGDFG | ubiquitination | [1] | | 1362 | NPDGATSKIFGFVAK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling (By similarity). |
Sequence Annotation | DOMAIN 122 294 Phosphatase tensin-type.
DOMAIN 299 425 C2 tensin-type.
DOMAIN 1131 1238 SH2.
ZN_FING 31 79 Phorbol-ester/DAG-type.
ACT_SITE 231 231 Phosphocysteine intermediate (By
MOD_RES 455 455 Phosphoserine.
MOD_RES 466 466 Phosphoserine.
MOD_RES 481 481 Phosphoserine.
MOD_RES 483 483 Phosphotyrosine.
MOD_RES 832 832 Phosphoserine.
MOD_RES 835 835 Phosphoserine.
MOD_RES 913 913 Phosphothreonine.
MOD_RES 1087 1087 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Complete proteome; Hydrolase; Membrane; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome; SH2 domain; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1400 AA |
Protein Sequence | MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK VTIDGTGVSC 60
RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 120
LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 180
KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 240
IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 300
PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL CISLEPALLL 360
KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK DQLDEAWADE RFPFQASVEF 420
VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGA LAHTRGPLDG 480
SPYAQVQRVP RQTPPAPSPE LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE 540
LDRLLGGCGV ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 600
PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG PYPYAPELGK 660
PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP TAALYGLRLE REAAEGWSSE 720
VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH 780
SGYPALVTYG YGGAVPSYCP AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ 840
PRKLGYEISA EDGRDKYPLS GHLASTGPLA STELFPPVSE SPEPSWRDGS SGHSTLPRSP 900
RDPQCSASSE LSGPSTPLHT SSPVQGKESN RRQDTTRSPS LAPTQRLSPG EALPSVVQGV 960
AEKTPELLTS SRPEQLDPSP FSQTSAPGSP NGWPQERSPG GHTNSASPRS PVPTTLPGLR 1020
HAPWQGPRGT SDSPDGSPLT PVPTQMPWLV GSPEPPQSSP TPAFPLATSY DANGPIQPPL 1080
PEKRHLPGSG QQPSPPARST NQHVTFASPL PDVTQPPEHP LQENQSNVKF VQDTSKFWYK 1140
PHLSRDQAIA LLKDKDPGAF LIRDSHSFQG AYGLALKVAT PPPSAQPWKG DPSEQLVRHF 1200
LIETGPKGVK IKGCPTEPYF GSLSALVSQH SISPISLPCC LRIPSKDPLE ETPEAPVPTN 1260
MSTAADLLRQ GAACSVLYLT SVETESLTGP QAVAKASSAA LSCSPVPVPA IVHFKVSAQG 1320
ITLTDNQRKL FFRRHYPVNS ITFSSTDPQD RRWTNPDGAT SKIFGFVAKK PGSPWENVCH 1380
LFAELDPDQP ASAIVTFITK VLLGQRK 1407 |
Gene Ontology | GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. GO:0019725; P:cellular homeostasis; IMP:MGI. GO:0032963; P:collagen metabolic process; IMP:MGI. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0001822; P:kidney development; IMP:MGI. GO:0035264; P:multicellular organism growth; IMP:MGI. GO:0048871; P:multicellular organismal homeostasis; IMP:MGI. GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. GO:0014850; P:response to muscle activity; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |