UniProt Accession

 DHSO_MOUSE; Q64442; Q569V5; Q9CPS0 

Genbank Protein ID

 U27014; AK004692; AK015059; AK166988; AK166996; AL844566; AL844573; AL844573; AL844566; BC024124; BC030875; BC092291 

Genbank Nucleotide ID

 AAA79043.1; BAB23478.1; BAB29695.1; BAE39168.1; BAE39175.1; CAM16325.1; CAM16325.1; CAM19389.1; CAM19389.1; AAH24124.1; AAH30875.1; AAH92291.1 

Protein Name

 Sorbitol dehydrogenase 

Protein Synonyms/Alias

 L-iditol 2-dehydrogenase 

Gene Name

 Sord 

Gene Synonyms/Alias

 Sdh1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MAAPAKGENLSLV	acetylation	[1, 2]
6	**MAAPAKGENLSLV	ubiquitination	[3]
63	RIGDFVVKKPMVLGH	acetylation	[1, 2, 4]
63	RIGDFVVKKPMVLGH	ubiquitination	[3]
64	IGDFVVKKPMVLGHE	ubiquitination	[3]
78	EAAGTVTKVGELVKH	ubiquitination	[3]
84	TKVGELVKHLKPGDR	acetylation	[2]
84	TKVGELVKHLKPGDR	ubiquitination	[3]
87	GELVKHLKPGDRVAI	acetylation	[2]
107	REVDEYCKIGRYNLT	ubiquitination	[3]
134	GNLCRFYKHNADFCY	acetylation	[2, 5]
134	GNLCRFYKHNADFCY	ubiquitination	[3]
226	DFTIQVGKETPQEIA	ubiquitination	[3]
295	AIREVDIKGVFRYCN	ubiquitination	[3]
319	ASKTLNVKPLVTHRF	acetylation	[2]
319	ASKTLNVKPLVTHRF	ubiquitination	[3]
330	THRFPLEKAVEAFET	acetylation	[1]
330	THRFPLEKAVEAFET	ubiquitination	[3]
339	VEAFETAKKGVGLKV	ubiquitination	[3]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. 

Sequence Annotation

 METAL 45 45 Zinc; catalytic (By similarity).
 METAL 70 70 Zinc; catalytic (By similarity).
 METAL 71 71 Zinc; catalytic (By similarity).
 BINDING 51 51 Substrate (By similarity).
 BINDING 156 156 Substrate (By similarity).
 BINDING 299 299 Substrate (By similarity).
 BINDING 300 300 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 169 169 Phosphoserine.  

Keyword

 Acetylation; Cell projection; Cilium; Complete proteome; Flagellum; Membrane; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0031514; C:motile cilium; IDA:UniProtKB.
 GO:0003939; F:L-iditol 2-dehydrogenase activity; IDA:MGI.
 GO:0051287; F:NAD binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046370; P:fructose biosynthetic process; IEA:Compara.
 GO:0051160; P:L-xylitol catabolic process; IEA:Compara.
 GO:0006062; P:sorbitol catabolic process; IEA:Compara.
 GO:0006060; P:sorbitol metabolic process; IDA:MGI.
 GO:0030317; P:sperm motility; IDA:UniProtKB. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS