CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011637
UniProt Accession
Genbank Protein ID
 L20820 
Genbank Nucleotide ID
Protein Name
 Syntaxin-3 
Protein Synonyms/Alias
  
Gene Name
 Stx3 
Gene Synonyms/Alias
 Stx3a 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
85EQLTTEIKKRANNVRacetylation[1]
100NKLKSMEKHIEEDEVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Potentially involved in docking of synaptic vesicles at presynaptic active zones. 
Sequence Annotation
 DOMAIN 191 253 t-SNARE coiled-coil homology.  
Keyword
 Coiled coil; Complete proteome; Membrane; Neurotransmitter transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 289 AA 
Protein Sequence
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY 60
SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH 120
SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG 180
IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV 240
DHVEKARDET KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK 289 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0042582; C:azurophil granule; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0030426; C:growth cone; IDA:HGNC.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0031201; C:SNARE complex; IDA:HGNC.
 GO:0042581; C:specific granule; IEA:Compara.
 GO:0050544; F:arachidonic acid binding; IDA:HGNC.
 GO:0006944; P:cellular membrane fusion; IDA:RGD.
 GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0046907; P:intracellular transport; TAS:RGD.
 GO:0031175; P:neuron projection development; IDA:HGNC.
 GO:0016081; P:synaptic vesicle docking involved in exocytosis; TAS:RGD. 
Interpro
 IPR015708; Syntaxin-3.
 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 
Pfam
 PF05739; SNARE
 PF00804; Syntaxin 
SMART
 SM00503; SynN
 SM00397; t_SNARE 
PROSITE
 PS00914; SYNTAXIN
 PS50192; T_SNARE 
PRINTS