CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014444
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicular glutamate transporter 1 
Protein Synonyms/Alias
 VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 
Gene Name
 Slc17a7 
Gene Synonyms/Alias
 Bnpi; Vglut1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
272SISEEERKYIEDAIGubiquitination[1]
283DAIGESAKLMNPVTKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. 
Sequence Annotation
  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Ion transport; Membrane; Neurotransmitter transport; Reference proteome; Sodium; Sodium transport; Symport; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 560 AA 
Protein Sequence
MEFRQEEFRK LAGRALGRLH RLLEKRQEGA ETLELSADGR PVTTHTRDPP VVDCTCFGLP 60
RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG HVVVQKAQFN WDPETVGLIH 120
GSFFWGYIVT QIPGGFICQK FAANRVFGFA IVATSTLNML IPSAARVHYG CVIFVRILQG 180
LVEGVTYPAC HGIWSKWAPP LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV 240
YGSFGIFWYL FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT 300
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV MTIIVPIGGQ 360
IADFLRSRHI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS KGVAISFLVL AVGFSGFAIS 420
GFNVNHLDIA PRYASILMGI SNGVGTLSGM VCPIIVGAMT KHKTREEWQY VFLIASLVHY 480
GGVIFYGVFA SGEKQPWAEP EEMSEEKCGF VGHDQLAGSD ESEMEDEVEP PGAPPAPPPS 540
YGATHSTVQP PRPPPPVRDY 560 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0060076; C:excitatory synapse; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IDA:RGD.
 GO:0043229; C:intracellular organelle; IDA:RGD.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0048786; C:presynaptic active zone; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005315; F:inorganic phosphate transmembrane transporter activity; IDA:RGD.
 GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; IDA:RGD.
 GO:0015319; F:sodium:inorganic phosphate symporter activity; IEA:Compara.
 GO:0051938; P:L-glutamate import; IEA:Compara.
 GO:0007616; P:long-term memory; IEA:Compara.
 GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0042137; P:sequestering of neurotransmitter; IEA:Compara.
 GO:0035249; P:synaptic transmission, glutamatergic; IEA:Compara. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS