UniProt Accession

 PAPOG_HUMAN; Q9BWT3; B2RBH4; Q969N1; Q9H8L2; Q9HAD0 

Genbank Protein ID

 AY029162; AF312211; AJ308101; AK021867; AK023544; AK314663; CH471053; BC111701; BC113747 

Genbank Nucleotide ID

 AAK31791.1; AAK83701.1; CAC59751.1; BAB13919.1; BAB14604.1; BAG37221.1; EAX00034.1; AAI11702.1; AAI13748.1 

Protein Name

 Poly(A) polymerase gamma 

Protein Synonyms/Alias

 PAP-gamma; Neo-poly(A) polymerase; Neo-PAP; Polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme 

Gene Name

 PAPOLG 

Gene Synonyms/Alias

 PAP2; PAPG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	GKLNNLVKEWISDVS	ubiquitination	[1]
135	FFQSFFEKLKHQDGI	ubiquitination	[1]
137	QSFFEKLKHQDGIRN	ubiquitination	[1]
341	TVMVEEFKQGLAVTD	ubiquitination	[1]
354	TDEILQGKSDWSKLL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. 

Sequence Annotation

 NP_BIND 99 101 ATP (By similarity).
 NP_BIND 112 114 ATP (By similarity).
 NP_BIND 245 246 ATP (By similarity).
 METAL 112 112 Magnesium 1; catalytic (By similarity).
 METAL 112 112 Magnesium 2; catalytic (By similarity).
 METAL 114 114 Magnesium 1; catalytic (By similarity).
 METAL 114 114 Magnesium 2; catalytic (By similarity).
 METAL 166 166 Magnesium 2; catalytic (By similarity).
 BINDING 108 108 ATP (By similarity).
 BINDING 166 166 ATP (By similarity).
 BINDING 227 227 ATP (By similarity).
 BINDING 236 236 ATP (By similarity).
 MOD_RES 2 2 N6-acetyllysine.
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 552 552 Phosphoserine (By similarity).
 MOD_RES 648 648 Phosphoserine.
 MOD_RES 654 654 Phosphothreonine.
 MOD_RES 684 684 Phosphoserine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Magnesium; Manganese; Metal-binding; mRNA processing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 736 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004652; F:polynucleotide adenylyltransferase activity; IBA:RefGenome.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006378; P:mRNA polyadenylation; IBA:RefGenome. 

Interpro

 IPR002934; Nucleotidyltransferase.
 IPR011068; NuclTrfase_I_C.
 IPR007012; PolA_pol_cen_dom.
 IPR007010; PolA_pol_RNA-bd_dom.
 IPR014492; PolyA_polymerase. 

Pfam

 PF01909; NTP_transf_2
 PF04928; PAP_central
 PF04926; PAP_RNA-bind 

SMART

  

PROSITE

  

PRINTS